| Zugriffsnummer | 44926 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Three-dimensional nanodosimetric characterisation of proton track structure |
| Autor(in); Institution |
Braunroth, Thomas; 6.5, Strahlenwirkung, PTB-Braunschweig; Gesellschaft für Anlagen- und Reaktorsicherheit, Köln, GERMANY
Nettelbeck, Heidi; 6.5, Strahlenwirkung, PTB-Braunschweig
Ngcezu, Sonwabile A.; National Metrology Institute of South Africa, Brummeria, SOUTH AFRICA; University of the Witwatersrand, Johannesburg, SOUTH AFRICA
Rabus, Hans; 6.5, Strahlenwirkung, PTB-Braunschweig
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| Quelle/Jahr | Radiation Physics and Chemistry: 176 (2020), 1 - 17 |
| Artikelnummer | 109066 |
| ISSN | 0969-806X |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | Nanodosimetry ; track structure ; proton therapy ; ionisation cluster size ; PTB high performance compute cluster |
| Zusammenfassung | This work presents a detailed investigation into the nanodosimetric properties of the track structure of protons in water at energies relevant for proton radiotherapy. The ionization component of the tracks had been simulated in previous work using Geant4-DNA for proton start energies between 1 MeV and 100 MeV. From the simulation results, the frequency distribution of ionization clusters formed in nanometric target volumes was obtained in dependence of the impact parameter of the proton trajectory with respect to the target center. In the track core, targets of cylindrical shape and a size comparable to a short segment of DNA were used for scoring ionization cluster size distributions. For the penumbra region, three different options for defining the cylinder shell sectors were investigated, with each cylinder shell sector volume the same as the cylinder target volume. The radial distributions were numerically integrated to obtain the effective track cross sections with respect to different nanodosimetric parameters. Graphically displaying the radial dependence in a similar way as microdosimetric distributions allowed elucidating the contribution of different radial distances to the overall radial integral of the quantities under consideration. Furthermore, it was tested how well the radial dependence of the nanodosimetric parameters could be fitted with a model function derived in literature for the radial energy deposition in proton tracks. It was found that this model function allows describing only the radial dependence of the total frequency of nanometric targets where ionizations occur. The deviation from a 1/r²-dependence of the radial dependence of the frequency of targets receiving more than a minimum number of ionizations (exceeding one) includes a second peak centred around 10 nm radial distance from the proton trajectory. Corrigendum: Radiation Physics and Chemistry Volume 186, September 2021, 109535 Corrigendum: Radiation Physics and Chemistry Volume 235, October 2025, 112826 |
| Relation |
https://doi.org/10.1016/j.radphyschem.2021.109535 – (Corrigendum von 2021)
https://doi.org/10.1016/j.radphyschem.2025.112826 – (Corrigendum von 2025)
https://doi.org/10.1016/j.radphyschem.2026.114009 – (Corrigendum von 2026)
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| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY-NC-ND 4.0 ; Creative Commons Attribution NonCommercial NoDerivatives 4.0 License |
| Themenbereich der Metrologie | Ionisierende Strahlung |