| Zugriffsnummer | 44769 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence |
| Autor(in); Institution |
Meng, W.; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, CHINA
Sjöholm, L.; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, SWEDEN
Kononenko, O.; Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, SWEDEN
Tay, N.; Centre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Zhang, D.; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, CHINA
Sarkisyan, D.; Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, SWEDEN
Geske, J.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
Ing, A.; Centre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Qiu, W.; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, CHINA
Watanabe, H.; Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, SWEDEN
Almamoun, R.; Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, SWEDEN
Frieling, H.; Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, GERMANY
Bleich, S.; Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, GERMANY
Cui, D.; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, CHINA
Biernacka, J.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
Mayfield, R.; The Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX, USA
Dang, Y.; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Zhongshan Hospital, Fudan University, Shanghai, CHINA
Karpyak, V.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
Schumann, G.; Centre for Population Neuroscience and Stratified Medicine (PONS), Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
IMAGEN Consortium,
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| Quelle/Jahr | Molecular Psychiatry:(2019) |
| ISSN | 1359-4184 (PRINT) ; 1476-5578 (ONLINE) |
| DOI | |
| Verlag | London: Springer Nature |
| Zusammenfassung | Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence. Methylation within DMR-DLGAP2 was found to be genotype-dependent, allele-specific and associated with reward processing in brain. Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls. These results suggest that DLGAP2 may be an interface for genetic and epigenetic factors controlling alcohol use and dependence. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Meng, W., Sjöholm, L., Kononenko, O., Tay, N., Zhang, D., Sarkisyan, D., Geske, J., Ing, A., Qiu, W., Watanabe, H., Almamoun, R., Frieling, H., Bleich, S., Cui, D., Biernacka, J., Mayfield, R., Dang, Y., Karpyak, V., Schumann, G., Ittermann, B., & IMAGEN Consortium. (2019). Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence. Molecular Psychiatry. https://doi.org/10.1038/s41380-019-0588-9