| Zugriffsnummer | 44737 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | The IMAGEN study: a decade of imaging genetics in adolescents |
| Autor(in); Institution |
Mascarell Maricic, L.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, GERMANY
Rosenthal, A.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, GERMANY
Ripke, S.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, GERMANY
Quinlan, E.; Department of Social Genetic & Developmental Psychiatry, Institute of Psychiatry, King's College London, London, UK
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, G.; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Desrivières, S.; Department of Social Genetic & Developmental Psychiatry, Institute of Psychiatry, King's College London, London, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Frouin, V.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging& Psychiatry”, University Paris Sud, University Paris Descartes - Sorbonne Paris Cité, and Maison de Solenn, Paris, FRANCE
Paillére Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes, Sorbonne Université, and AP-HP, Department of Child and Adolescent Psychiatry, Pitié- Salp
Nees, F.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur- Yvette, FRANCE
Paus, T.; Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Kaminski, J.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, GERMANY
Schumann, G.; Department of Social Genetic & Developmental Psychiatry, Institute of Psychiatry, King's College London, London, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, GERMANY
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| Quelle/Jahr | Molecular Psychiatry: 25 (2020), 2648 - 2671 |
| ISSN | 1359-4184 (PRINT) ; 1476-5578 (ONLINE) |
| DOI | |
| Verlag | Basingstoke: Springer Nature |
| Zusammenfassung | Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Mascarell Maricic, L., Walter, H., Rosenthal, A., Ripke, S., Quinlan, E., Banaschewski, T., Barker, G., Bokde, A., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Ittermann, B., Martinot, J.-L., Paillére Martinot, M.-L., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Hohmann, S., Smolka, M., Fröhner, J., Whelan, R., Kaminski, J., Schumann, G., & Heinz, A. (2020). The IMAGEN study: a decade of imaging genetics in adolescents. Molecular Psychiatry, 25, 2648–2671. https://doi.org/10.1038/s41380-020-0822-5