| Zugriffsnummer | 44727 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents |
| Autor(in); Institution |
Kühn, S.; University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, GERMANY
Mascherek, A.; University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Quinlan, E.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UNITED KINGDOM
Desrivières, S.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UNITED KINGDOM
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UNITED KINGDOM
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes - Sorbonne Paris Cité; and Maison de Solenn, Paris, FRANCE
Paillére Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud, University Paris Descartes - Sorbonne Paris Cité; and Maison de Solenn, Paris, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Millenet, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UNITED KINGDOM
Lindenberger, U.; Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, GERMANY
Gallinat, J.; University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, GERMANY
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| Quelle/Jahr | Scientific Reports: 10 (2020), 10 S. |
| Artikelnummer | 1207 |
| Availability | [online only] |
| ISSN | 2045-2322 |
| DOI | |
| Verlag | London: Nature Publ. |
| Zusammenfassung | Adolescence is a vulnerable time for personality development. Especially neuroticism with its link to the development of psychopathology is of interest concerning influential factors. The present study exploratorily investigates neuroanatomical signatures for developmental trajectories of neuroticism based on a voxel-wise whole-brain structural equation modelling framework. In 1,814 healthy adolescents of the IMAGEN sample, the NEO-FFI was acquired at three measurement occasions across five years. Based on a partial measurement invariance second-order latent growth curve model we conducted whole-brain analyses on structural MRI data at age 14 years, predicting change in neuroticism over time. We observed that a reduced volume in the pituitary gland was associated with the slope of neuroticism over time. However, no relations with prefrontal areas emerged. Both findings are discussed against the background of possible genetic and social influences that may account for this result. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Kühn, S., Mascherek, A., Banaschewski, T., Bokde, A., Büchel, C., Quinlan, E., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paillére Martinot, M.-L., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Millenet, S., Fröhner, J., Smolka, M., Walter, H., Whelan, R., Schumann, G., Lindenberger, U., & Gallinat, J. (2020). Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents. Scientific Reports, 10, 10 S. https://doi.org/10.1038/s41598-020-58128-x