| Zugriffsnummer | 44723 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Neural correlates of adolescent irritability and its comorbidity with psychiatric disorders |
| Autor(in); Institution |
Chaarani, B.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Kan, K.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Mackey, S.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Spechler, P.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Potter, A.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Millenet, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANYMannheim, Germany
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, IRELAND
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Cattrell, A.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
Conrod, P.; Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, CANADA; Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
Desrivières, S.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Frouin, V.; Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, FRANCE
Gallinat, J.; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, GERMANY
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UUK
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging& Psychiatry”, University Paris Sud, University Paris Descartes - Sorbonne Paris Cité, and Maison de Solenn, Paris, FRANCE
Nees, F.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Paus, T.; Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Stringaris, A.; National Institute of Mental Health/NIH, Bethesda, MD, USA
Higgins, S.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA
Schumann, G.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Althoff, R.; Vermont Center on Behavior and Health, University of Vermont, Burlington, USA
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| Quelle/Jahr | Journal of the American Academy of Child and Adolescent Psychiatry: 59 (2020), 12, P1371 - P1379 |
| ISSN | 0890-8567 (PRINT) ; 1527-5418 (ONLINE) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | adolescent irritability ; grey matter volume ; inhibitory control ; psychopathology |
| Zusammenfassung | Objective: Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. Here, we examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2024 14-year-adolescents from five European countries. Method: The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), oppositional defiant disorder (ODD), and generalized anxiety (GA). Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural MRI was examined using whole brain Voxel Based Morphometry analysis and functional MRI was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models (SEM) to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses. Results: Whole brain voxel wise analysis showed that adolescent irritable mood was associated with less grey matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p(0.05). SEM models suggested that part of the observed smaller GMV is exclusively driven by irritability separate from direct relationships between GA (or ADHD, MDD, ODD) and grey matter volume. Conclusion: This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Chaarani, B., Kan, K., Mackey, S., Spechler, P., Potter, A., Banaschewski, T., Millenet, S., Bokde, A., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Nees, F., Paus, T., Poustka, L., Smolka, M., Walter, H., Whelan, R., Stringaris, A., Higgins, S., Schumann, G., Garavan, H., & Althoff, R. (2020). Neural correlates of adolescent irritability and its comorbidity with psychiatric disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 59(12), P1371–P1379. https://doi.org/10.1016/j.jaac.2019.11.028