| Zugriffsnummer | 44722 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents |
| Autor(in); Institution |
Spechler, P.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA
Chaarani, B.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA
Orr, C.; Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA
Albaugh, M.; Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA
Fontaine, N.; Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA
Higgins, S.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA
Banaschewski, T.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, IRELAND
Quinlan, E.; Centre for Population Neuroscience and StratifiedMedicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Desriviéres, S.; Centre for Population Neuroscience and StratifiedMedicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur- Yvette, FRANCE
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Artiges, E.; Institut National de la Santé et de la Recherche Médicale, INSERM UA10 “Trajectoires développementales en psychiatrie”, Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; and Psychiatry Department, Orsay Hospital, Paris, FRANCE
Paillére Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM UA10 “Trajectoires développementales en psychiatrie”, Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli; and AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Nees, F.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Paus, T.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Paris, FRANCE
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Child andAdolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, GERMANY
Walter, H.; NDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Garavan, H.; Vermont Center on Behavior and Health, Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA
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| Quelle/Jahr | Psychopharmacology: 237 (2020), 3447 - 3458 |
| ISSN | 0033-3158 (PRINT) ; 1432-2072 (ONLINE) |
| DOI | |
| Verlag | Berlin: Springer |
| Freie Schlagworte | Adolescence ; Amygdala; Cannabis ; Emotion ; Face processing ; Faces ; fMRI |
| Zusammenfassung | Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n=70) of 14-year olds with a history of cannabis use to a group (n=70) of never-using controls matched on numerous characteristics including IQ, SES, alcohol and cigarette use. The task contained short movies displaying angry and neutral faces. Results indicated that cannabis users had greater reactivity in the bilateral amygdalae to angry faces than neutral faces, an effect that was not observed in their abstinent peers. In contrast, activity levels in the cannabis users in cortical areas including the right temporal-parietal junction and bilateral dorsolateral prefrontal cortex did not discriminate between the two face conditions, but did differ in controls. Results did not change after excluding subjects with any psychiatric symptomology. Given the high density of cannabinoid receptors in the amygdala, our findings suggest cannabis use in early adolescence is associated with hypersensitivity to signals of threat. Hypersensitivity to negative affect in adolescence may place the subject at-risk for mood disorders in adulthood. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Spechler, P., Chaarani, B., Orr, C., Albaugh, M., Fontaine, N., Higgins, S., Banaschewski, T., Bokde, A., Quinlan, E., Desriviéres, S., Flor, H., Grigis, A., Gowland, P., Heinz, A., Ittermann, B., Artiges, E., Paillére Martinot, M.-L., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Hohmann, S., Fröhner, J., Smolka, M., Walter, H., Whelan, R., Schumann, G., & Garavan, H. (2020). Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents. Psychopharmacology, 237, 3447–3458. https://doi.org/10.1007/s00213-020-05624-7