| Zugriffsnummer | 44720 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
| Autor(in); Institution |
Papanastasiou, E.; Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
Mouchlianitis, E.; Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
Joyce, D.; Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
McGuire, P.; Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
Boussebaa, C.; Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Büchel, C.; Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Quinlan, E.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
Desrivières, S.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, A.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Department of Psychiatry, University of Vermont, Burlington, Vermont, USA
Spechler, P.; Department of Psychiatry, University of Vermont, Burlington, Vermont, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UNITED KINGDOM
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Paillére Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, Neuroimaging & Psychiatry, University Paris Sud – Paris-Saclay, University Paris Descartes, Paris, FRANCE
Artiges, E.; Institut National de la Santé et de la Recherche Médicale, Neuroimaging & Psychiatry, DIGITEO Labs, University Paris Saclay, Gif-sur-Yvette, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Millenet, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry Psychology and Neuroscience, King’s College London, London, UNITED KINGDOM
Sukhwinder, S.; Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King’s College London, London, UNITED KINGDOM
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| Quelle/Jahr | Scientific Reports: 10 (2020) |
| Artikelnummer | 5164 |
| Availability | [online only] |
| ISSN | 2045-2322 |
| DOI | |
| Verlag | Springer Nature |
| Zusammenfassung | Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential 'aberrant' neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Papanastasiou, E., Mouchlianitis, E., Joyce, D., McGuire, P., Boussebaa, C., Banaschewski, T., Bokde, A., Büchel, C., Quinlan, E., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Spechler, P., Gowland, P., Heinz, A., Ittermann, B., Paillére Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Millenet, S., Fröhner, J., Smolka, M., Walter, H., Whelan, R., Schumann, G., & Sukhwinder, S. (2020). Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces. Scientific Reports, 10. https://doi.org/10.1038/s41598-020-62026-7