| Zugriffsnummer | 44713 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Development of disordered eating behaviors and comorbid depressive symptoms in adolescence: neural and psychopathological predictors |
| Autor(in); Institution |
Zhang, Z.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UNITED KINGDOM
Robinson, L.; Section of Eating Disorders, Department of Psychological Medicine, London, UNITED KINGDOM
Jia, T.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UNITED KINGDOM; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, CHINA; Ministry of Education-Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, CHINA
Quinlan, E.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UNITED KINGDOM
Tay, N.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom
Chu, C.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom
Barker, E.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom; Developmental Psychopathology Lab, Department of Psychology, King's College London, London, United Kingdom
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, G.; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UNITED KINGDOM
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin, IRELAND
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Grigis, A.; NeuroSpin, Commissariat à l'Énergie Atomique, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UNITED KINGDOM
Heinz, A.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Charite Mitte, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry”, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette, FRANCE
Stringaris, A.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Penttilä, J.; Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic, Lahti, FINLAND
van Noort, B.; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Humboldt University, Berlin, GERMANY
Grimmer, Y.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Palliére Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry”, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette, FRANCE
Isensee, C.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Becker, A.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfandos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK
Schmidt, U.; Section of Eating Disorders, Department of Psychological Medicine, London, UK
Desvières, S.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
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| Quelle/Jahr | Biological Psychiatry: 90 (2021), 12, 853 - 862 |
| ISSN | 0006-3223 (PRINT) ; 1873-2402 (ONLINE) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | Attention-deficit/hyperactivity disorder ; Biomarkers ; Conduct disorder ; Depression ; Eating disorders ; Gray matter volume |
| Zusammenfassung | Background: Eating disorders are common in adolescence and are devastating and strongly comorbid with other psychiatric disorders. Yet little is known about their etiology, knowing which would aid in developing effective preventive measures. Methods: Longitudinal assessments of disordered eating behaviors (DEBs)-binge-eating, purging, and dieting-and comorbid psychopathology were measured in 1386 adolescents from the IMAGEN study. Development of DEBs and associated mental health problems was investigated by comparing participants who reported symptoms at ages 16 or 19 years, but not at age 14 years, with asymptomatic control participants. Voxel-based morphometry and psychopathological differences at age 14 were investigated to identify risk factors for the development of DEBs and associated mental health problems. Results: DEBs and depressive symptoms developed together. Emotional and behavioral problems, including symptoms of attention-deficit/hyperactivity disorder and conduct disorder, predated their development. Alterations in frontostriatal brain areas also predated the development of DEBs and depressive symptoms. Specifically, development of binge-eating was predicted by higher gray matter volumes in the right putamen/globus pallidus at age 14. Conversely, development of purging and depressive symptoms was predicted by lower volumes in the medial orbitofrontal, dorsomedial, and dorsolateral prefrontal cortices. Lower gray matter volumes in the orbitofrontal and anterior cingulate cortices mediated the relationship between attention-deficit/hyperactivity disorder and conduct disorder symptoms and future purging and depressive symptoms. Conclusions: These findings suggest that alterations in frontal brain circuits are part of the shared etiology among eating disorders, attention-deficit/hyperactivity disorder, conduct disorder, and depression and highlight the importance of a transdiagnostic approach to treating these conditions. |
| Kostenfreier Zugang | Open Access Hybrid |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Zhang, Z., Robinson, L., Jia, T., Quinlan, E., Tay, N., Chu, C., Barker, E., Banaschewski, T., Barker, G., Bokde, A., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Stringaris, A., Penttilä, J., van Noort, B., Grimmer, Y., Palliére Martinot, M.-L., Isensee, C., Becker, A., Nees, F., Papadopoulos Orfandos, D., Paus, T., Poustka, L., Hohmann, S., Fröhner, J., Smolka, M., Walter, H., Whelan, R., Schumann, G., Schmidt, U., & Desvières, S. (2021). Development of disordered eating behaviors and comorbid depressive symptoms in adolescence: neural and psychopathological predictors. Biological Psychiatry, 90(12), 853–862. https://doi.org/10.1016/j.biopsych.2020.06.003