| Zugriffsnummer | 44711 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment |
| Autor(in); Institution |
Judd, N.; Department of Neuroscience, Karolinska Institute, Stockholm, SWEDEN
Sauce, B.; Department of Neuroscience, Karolinska Institute, Stockholm, SWEDEN
Wiedenhoeft, J.; Department of Medical Statistics, University of Göttingen, Göttingen, GERMANY
Tromp, J.; Department of Cognitive Psychology, Leiden University, Leiden, THE NETHERLANDS
Chaarani, B.; Department of Psychiatry, University of Vermont, Burlington, VT , USA
Schliep, A.; Department of Computer Science and Engineering, University of Gothenburg, Gothenburg, SWEDEN
van Noort, B.; Hochschule für Gesundheit und Medizin, Medical School Berlin, Berlin, GERMANY
Penttilä, J.; Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic, University of Tampere, Lahti, FINLAND
Grimmer, Y.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Insensee, C.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, GERMANY
Becker, A.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND
Quinlan, E.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UNITED KINGDOM
Desrivières, S.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UNITED KINGDOM
Flor, H.; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, A.; NeuroSpin, French Alternative Energies and Atomic Energy Commission (CEA), Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Gowland, P.; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UNITED KINGDOM
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; INSERM Unit 1000 “Neuroimaging & Psychiatry,” Institut National de la Santé et de la Recherche Médicale, University Paris Saclay, University Paris Descartes, Paris, FRANCE
Palliére Martinot, M.-L.; INSERM Unit 1000 “Neuroimaging & Psychiatry,” Institut National de la Santé et de la Recherche Médicale, University Paris Saclay, University Paris Descartes, Paris, FRANCE
Artiges, E.; INSERM Unit 1000 “Neuroimaging & Psychiatry,” Institut National de la Santé et de la Recherche Médicale, University Paris Saclay, University Paris Descartes, Paris, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, French Alternative Energies and Atomic Energy Commission (CEA), Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Millenet, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Smolka, M.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; School of Psychology, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UNITED KINGDOM
Garavan, H.; Department of Psychiatry, University of Vermont, Burlington, VT, USA
Klingberg, T.; Department of Neuroscience, Karolinska Institute, Stockholm, SWEDEN
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| Quelle/Jahr | Proceedings of the National Academy of Sciences of the United States of America: 117 (2020), 22, 12411 - 12418 |
| ISSN | 0027-8424 (PRINT) ; 1091-6490 (ONLINE) |
| DOI | |
| Verlag | National Academy of Sciences |
| Freie Schlagworte | development ; polygenic scores ; socioeconomic status ; structural MRI ; working memory |
| Zusammenfassung | Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, and both have been associated with variations in brain structure and cognition. However, genetics and SES are correlated, and no prior study has assessed their neural associations independently. Here we used a polygenic score for educational attainment (EduYears-PGS), as well as SES, in a longitudinal study of 551 adolescents to tease apart genetic and environmental associations with brain development and cognition. Subjects received a structural MRI scan at ages 14 and 19. At both time points, they performed three working memory (WM) tasks. SES and EduYears-PGS were correlated (r = 0.27) and had both common and independent associations with brain structure and cognition. Specifically, lower SES was related to less total cortical surface area and lower WM. EduYears-PGS was also related to total cortical surface area, but in addition had a regional association with surface area in the right parietal lobe, a region related to nonverbal cognitive functions, including mathematics, spatial cognition, and WM. SES, but not EduYears-PGS, was related to a change in total cortical surface area from age 14 to 19. This study demonstrates a regional association of EduYears-PGS and the independent prediction of SES with cognitive function and brain development. It suggests that the SES inequalities, in particular parental education, are related to global aspects of cortical development, and exert a persistent influence on brain development during adolescence. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Judd, N., Sauce, B., Wiedenhoeft, J., Tromp, J., Chaarani, B., Schliep, A., van Noort, B., Penttilä, J., Grimmer, Y., Insensee, C., Becker, A., Banaschewski, T., Bokde, A., Quinlan, E., Desrivières, S., Flor, H., Grigis, A., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Palliére Martinot, M.-L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Hohmann, S., Millenet, S., Fröhner, J., Smolka, M., Walter, H., Whelan, R., Schumann, G., Garavan, H., & Klingberg, T. (2020). Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment. Proceedings of the National Academy of Sciences of the United States of America, 117(22), 12411–12418. https://doi.org/10.1073/pnas.2001228117