Association of gray matter and personality development with increased drunkenness frequency during adolescence

Robert, G.; Luo, Q.; Chu, C.; Ing, A.; Jia, T.; Orfanos, D.; Burke-Quinlan, E.; Desrivières, S.; Ruggeri, B.; Spechler, P.; Chaarani, B.; Tay, N.; Banaschewski, T.; Bokde, A.; Bromberg, U.; Flor, H.; Frouin, V.; Gowland, P.; Heinz, A.; Ittermann, Bernd; Martinot, J.-L.; Paillère Martinot, M.-L.; Nees, F.; Poustka, L.; Smolka, M.; Vetter, N.; Walter, H.; Whelan, R.; Conrod, P.; Barker, T.; Garavan, H.; Schumann, G.

doi:https://doi.org/10.1001/jamapsychiatry.2019.4063

Zugriffsnummer	44709
Dokumenttyp	Zeitschriftenartikel
Peer Review	mit Peer Review
Sprache	Englisch
Titel	Association of gray matter and personality development with increased drunkenness frequency during adolescence
Autor(in); Institution	Robert, G.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Luo, Q.; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, CHINA Chu, C.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Ing, A.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Jia, T.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Orfanos, D.; Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY Burke-Quinlan, E.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Desrivières, S.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Ruggeri, B.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Spechler, P.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA Chaarani, B.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA Tay, N.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Bokde, A.; School of Medicine and Trinity College Institute of Neuroscience, Discipline of Psychiatry, Trinity College Dublin, Dublin, IRELAND Bromberg, U.; Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Frouin, V.; Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, Faculté de Médecine, Université Paris-Sud, Le Kremlin-Bicêtre, Sorbonne Paris Cité, Paris, FRANCE Paillère Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, Université Paris-Sud, University Paris Descartes-Sorbonne Paris Citél, Paris, FRANCE Nees, F.; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AUSTRIA Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY Vetter, N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Research Division of Mind and Brain Berlin, Berlin, GERMANY Whelan, R.; Department of Psychology, University College Dublin, Belfield, Dublin, IRELAND Conrod, P.; Department of Psychiatry and Addictology, Medical Faculty, University of Montreal, Montréal, Québec, CANADA Barker, T.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA Schumann, G.; Institute of Psychiatry, Psychology and Neuroscience, Centre for Population Neuroscience and Stratified Medicine (PONS), King's College London, London, UK
Quelle/Jahr	JAMA Psychiatry: 77 (2020), 4, 409 - 419
ISSN	2168-622X (PRINT) ; 2168-6238 (ONLINE)
DOI	https://doi.org/10.1001/jamapsychiatry.2019.4063
Verlag	Chicago, Ill.: American Medical Association
Zusammenfassung	Importance: Alcohol abuse correlates with gray matter development in adolescents, but the directionality of this association remains unknown. Objective: To investigate the directionality of the association between gray matter development and increase in frequency of drunkenness among adolescents. Design, setting, and participants: This cohort study analyzed participants of IMAGEN, a multicenter brain imaging study of healthy adolescents in 8 European sites in Germany (Mannheim, Dresden, Berlin, and Hamburg), the United Kingdom (London and Nottingham), Ireland (Dublin), and France (Paris). Data from the second follow-up used in the present study were acquired from January 1, 2013, to December 31, 2016, and these data were analyzed from January 1, 2016, to March 31, 2018. Analyses were controlled for sex, site, socioeconomic status, family history of alcohol dependency, puberty score, negative life events, personality, cognition, and polygenic risk scores. Personality and frequency of drunkenness were assessed at age 14 years (baseline), 16 years (first follow-up), and 19 years (second follow-up). Structural brain imaging scans were acquired at baseline and second follow-up time points. Main outcomes and measures: Increases in drunkenness frequency were measured by latent growth modeling, a voxelwise hierarchical linear model was used to observe gray matter volume, and tensor-based morphometry was used for gray matter development. The hypotheses were formulated before the data analyses. Results: A total of 726 adolescents (mean [SD] age at baseline, 14.4 [0.38] years; 418 [58%] female) were included. The increase in drunkenness frequency was associated with accelerated gray matter atrophy in the left posterior temporal cortex (peak: t_1,710 = -5.8; familywise error (FWE)-corrected P = 7.2 × 10^-5; cluster: 6297 voxels; P = 2.7 × 10^-5), right posterior temporal cortex (cluster: 2070 voxels; FWE-corrected P = .01), and left prefrontal cortex (peak: t_1,710 = -5.2; FWE-corrected P = 2 × 10^-3; cluster: 10 624 voxels; P = 1.9 × 10^-7). According to causal bayesian network analyses, 73% of the networks showed directionality from gray matter development to drunkenness increase as confirmed by accelerated gray matter atrophy in late bingers compared with sober controls (n = 20 vs 60; β = 1.25; 95% CI, -2.15 to -0.46; t_1,70 = 0.3; P = .004), the association of drunkenness increase with gray matter volume at age 14 years (β = 0.23; 95% CI, 0.01-0.46; t_1,584 = 2; P = .04), the association between gray matter atrophy and alcohol drinking units (β = -0.0033; 95% CI, -6 × 10^-3 to -5 × 10^-4; t1,509 = -2.4; P = .02) and drunkenness frequency at age 23 years (β = -0.16; 95% CI, -0.28 to -0.03; t_1,533 = -2.5; P = .01), and the linear exposure-response curve stratified by gray matter atrophy and not by increase in frequency of drunkenness. Conclusions and relevance: This study found that gray matter development and impulsivity were associated with increased frequency of drunkenness by sex. These results suggest that neurotoxicity-related gray matter atrophy should be interpreted with caution.

Themenbereich der Metrologie

Metrologie in der Medizin

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Robert, G., Luo, Q., Chu, C., Ing, A., Jia, T., Orfanos, D., Burke-Quinlan, E., Desrivières, S., Ruggeri, B., Spechler, P., Chaarani, B., Tay, N., Banaschewski, T., Bokde, A., Bromberg, U., Flor, H., Frouin, V., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Nees, F., Poustka, L., Smolka, M., Vetter, N., Walter, H., Whelan, R., Conrod, P., Barker, T., Garavan, H., & Schumann, G. (2020). Association of gray matter and personality development with increased drunkenness frequency during adolescence. JAMA Psychiatry, 77(4), 409–419. https://doi.org/10.1001/jamapsychiatry.2019.4063

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