| Zugriffsnummer | 44675 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Radiofrequency applicator concepts for thermal magnetic resonance of brain tumors at 297 MHz (7.0 Tesla) |
| Autor(in); Institution |
Oberacker, E.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY; Department of Physics, Faculty of Mathematics and Natural Sciences, Humboldt-Universität zu Berlin, Berlin, GERMANY
Kuehne, A.; MRI.TOOLS GmbH, Berlin, GERMANY
Oezerdem, C.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY
Nadobny, J.; Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GERMANY
Weihrauch, M.; Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GERMANY
Beck, M.; Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GERMANY
Zschaeck, S.; Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GERMANY
Diesch, C.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY
Eigentler, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY
Waiczies, H.; MRI.TOOLS GmbH, Berlin, GERMANY
Ghadjar, P.; Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GERMANY
Wust, P.; Clinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GERMANY
Winter, Lukas; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Niendorf, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY
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| Quelle/Jahr | International Journal of Hyperthermia: 37 (2020), 1, 549 - 563 |
| ISSN | 0265-6736 (PRINT) ; 1464-5157 (ONLINE) |
| DOI | |
| Verlag | New York, NY: Taylor & Francis |
| Freie Schlagworte | Hyperthermia ; Thermal Magnetic Resonance ; Magnetic Resonance Imaging ; Radiofrequency Antennas ; Electromagnetic Field Simulations |
| Zusammenfassung | Purpose: Thermal intervention is a potent sensitizer of cells to chemo- and radiotherapy in cancer treatment. Glioblastoma multiforme (GBM) is a potential clinical target, given the cancer’s aggressive nature and resistance to current treatment options. The annular phased array (APA) technique employing electromagnetic waves in the radiofrequency (RF) range allows for localized temperature increase in deep seated target volumes (TVs). Reports on clinical applications of the APA technique in the brain are still missing. Ultrahigh field magnetic resonance (MR) employs higher frequencies than conventional MR and has potential to provide focal temperature manipulation, high resolution imaging and noninvasive temperature monitoring using an integrated RF applicator (ThermalMR). This work examines the applicability of RF applicator concepts for ThermalMR of brain tumors at 297 MHz (7.0 Tesla). Methods: Electromagnetic field (EMF) simulations are performed for clinically realistic data based on GBM patients. Two algorithms are used for specific RF energy absorption rate based thermal intervention planning for small and large TVs in the brain, aiming at maximum RF power deposition or RF power uniformity in the TV for 10 RF applicator designs. Results: For both TVs , the power optimization outperformed the uniformity optimization. The best results for the small TV are obtained for the 16 element interleaved RF applicator using an elliptical antenna arrangement with water bolus. The two row elliptical RF applicator yielded the best result for the large TV. Discussion: This work investigates the capacity of ThermalMR to achieve targeted thermal interventions in model systems resembling human brain tissue and brain tumors. The compact SGBT antenna building block provides technology for the design of integrated high‐density RF applicators and for the study of the role of temperature in (patho‐) physiological processes by adding a thermal intervention dimension to an MRI device (Thermal MR). |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Oberacker, E., Kuehne, A., Oezerdem, C., Nadobny, J., Weihrauch, M., Beck, M., Zschaeck, S., Diesch, C., Eigentler, T., Waiczies, H., Ghadjar, P., Wust, P., Winter, L., & Niendorf, T. (2020). Radiofrequency applicator concepts for thermal magnetic resonance of brain tumors at 297 MHz (7.0 Tesla). International Journal of Hyperthermia, 37(1), 549–563. https://www.tandfonline.com/doi/full/10.1080/02656736.2020.1761462