Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions

Schuemann, Jan; Bagley, Alexander F.; Berbeco, Ross; Bromma, Kyle; Butterworth, Karl T.; Byrne, H.; Chithrani, Devika; Cho, Sang Hyun; Cook, Jason R.; Favaudon, Vincent; Gholami, Y.; Gargioni, Elisabetta; Hainfeld, James F.; Hespeels, Felicien; Heuskin, Anne-Catherine; Ibeh, Udoka M.; Kuncic, Z.; Kunjachan, Sijumon; Lacombe, Sandrine; Lucas, Stephane; Lux, Francois; McMahon, Stephen; Nevozhay, Dmitry; Ngwa, Wilfred; Payne, J. Donald; Penninckx, Sebastien; Porcel, Erika; Prise, Kevin M.; Rabus, Hans; Rudek, Benedikt; Sanche, Leon; Singh, Bijay; Sokolov, Konstantin V.; Sridhar, Srinivas; Sung, Wonmo; Tillement, Olivier; Virani, Needa; Yantasee, Wassana; Krishnan, Sunil

doi:https://doi.org/10.1088/1361-6560/ab9159

Zugriffsnummer	44652
Dokumenttyp	Zeitschriftenartikel
Peer Review	mit Peer Review
Sprache	Englisch
Titel	Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
Autor(in); Institution	Schuemann, Jan; Massachusetts General Hospital & Harvard Medical School, Department of Radiation Oncology, Boston, USA Bagley, Alexander F.; The University of Texas MD Anderson Cancer Center, Department of Radiation Oncology, Houston, USA Berbeco, Ross; Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Department of Radiation Oncology, Boston, USA Bromma, Kyle; University of Victoria, Department of Physics and Astronomy, Victoria, CANADA Butterworth, Karl T.; Queen’s University Belfast, Centre for Cancer Research and Cell Biology, Belfast, UK Byrne, H.; The University of Sydney, Faculty of Science, Institute of Medical Physics, School of Physics, AUSTRALIA Chithrani, Devika; University of Victoria, Department of Physics and Astronomy, Victoria, CANADA Cho, Sang Hyun; The University of Texas, Department of Radiation Physics & Department of Imaging Physics, USA Cook, Jason R.; NanoHybrids, Austin, USA Favaudon, Vincent; University Paris Sud, Institut Curie, University Paris-Saclay, Orsay, FRANCE Gholami, Y.; The University of Sydney, Faculty of Science, Institute of Medical Physics, School of Physics, AUSTRALIA Gargioni, Elisabetta; University medical center Hamburg-Eppendorf, Department of Radiotherapy and Radiation Oncology, Hamburg, GERMANY Hainfeld, James F.; Nanoporbes, Yaphank, USA Hespeels, Felicien; University of Namur, NAmur Research Institute for LIfe Sciences (NARILIS), Laboratory of Analysis by Nuclear Reactions, Namur, BELGIUM Heuskin, Anne-Catherine; University of Namur, NAmur Research Institute for LIfe Sciences (NARILIS), Laboratory of Analysis by Nuclear Reactions, Namur, BELGIUM Ibeh, Udoka M.; Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Department of Radiation Oncology, Boston, USA Kuncic, Z.; The University of Sydney, Faculty of Science, Institute of Medical Physics, School of Physics, AUSTRALIA; The University of Sydney Nano Institute, AUSTRALIA Kunjachan, Sijumon; Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Department of Radiation Oncology, Boston, USA Lacombe, Sandrine; University Paris-Saclay, University Paris Sud, Orsay, FRANCE Lucas, Stephane; University of Namur, NAmur Research Institute for LIfe Sciences (NARILIS), Laboratory of Analysis by Nuclear Reactions, Namur, BELGIUM Lux, Francois; NH TherAguix SAS, Villeurbanne, FRANCE; Universite Claude Bernard Lyon 1, Institut Lumiere Matiere, Lyon, FRANCE McMahon, Stephen; Queen’s University Belfast, Centre for Cancer Research and Cell Biology, Belfast, UK Nevozhay, Dmitry; The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, Houston, USA; Far Eastern Federal University, School of Biomedicine, Vladivostok, RUSSIA Ngwa, Wilfred; Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Department of Radiation Oncology, Boston, USA Payne, J. Donald; Aurorad, Houston, USA Penninckx, Sebastien; University of Namur, NAmur Research Institute for LIfe Sciences (NARILIS), Laboratory of Analysis by Nuclear Reactions, Namur, BELGIUM Porcel, Erika; University Paris-Saclay, University Paris Sud, Orsay, FRANCE Prise, Kevin M.; Queen’s University Belfast, Centre for Cancer Research and Cell Biology, Belfast, UK Rabus, Hans; 6.5, Strahlenwirkung, PTB-Braunschweig Rudek, Benedikt; Massachusetts General Hospital & Harvard Medical School, Department of Radiation Oncology, Boston, USA; 6.5, Strahlenwirkung, PTB-Braunschweig; Boston University, Boston, USA Sanche, Leon; Université de Sherbrooke, Department of nuclear medicine and radiobiology, Sherbrooke, CANADA Singh, Bijay; Northeastern University, Department of Physics, Boston, USA Sokolov, Konstantin V.; The University of Texas MD Anderson Cancer Center, Department of Imaging Physics, Houston, USA; Rice University, Department of Bioengineering, Houston, USA; The University of Texas at Austin, Department of Biomedical Engineering, Austin, USA Sridhar, Srinivas; Northeastern University, Department of Physics, Boston, USA Sung, Wonmo; Massachusetts General Hospital & Harvard Medical School, Department of Radiation Oncology, Boston, USA Tillement, Olivier; NH TherAguix SAS, Villeurbanne, FRANCE; Universite Claude Bernard Lyon 1, Institut Lumiere Matiere, Lyon, FRANCE Virani, Needa; Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Department of Radiation Oncology, Boston, USA Yantasee, Wassana; Oregon Health & Science University, Department of Biomedical Engineering, Portland, USA Krishnan, Sunil; Mayo Clinic Florida, Department of Radiation Oncology, Jacksonville, USA
Quelle/Jahr	Physics in Medicine and Biology: 65 (2020), 21, 1 - 64
Artikelnummer	21RM02
ISSN	0031-9155 (PRINT) ; 1361-6560 (ONLINE)
DOI	https://doi.org/10.1088/1361-6560/ab9159
Verlag	Bristol: IOP Publishing
Freie Schlagworte	Metallic nanoparticles ; dose enhancement ; theranostic
Zusammenfassung	This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy, …) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

Themenbereich der Metrologie	Ionisierende Strahlung
Förderinformationen (1)	Förderername: Deutsche Forschungsgemeinschaft (DFG) Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Titel der Förderung: Elektronenemissionsspektren von Gold-Nanopartikeln zur Dosisberechnung in der Strahlentherapie Förderungsnummer: 386872118 URI der Förderung: https://gepris.dfg.de/gepris/projekt/386872118

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Schuemann, J., Bagley, A. F., Berbeco, R., Bromma, K., Butterworth, K. T., Byrne, H., Chithrani, D., Cho, S. H., Cook, J. R., Favaudon, V., Gholami, Y., Gargioni, E., Hainfeld, J. F., Hespeels, F., Heuskin, A.-C., Ibeh, U. M., Kuncic, Z., Kunjachan, S., Lacombe, S., Lucas, S., Lux, F., McMahon, S., Nevozhay, D., Ngwa, W., Payne, J. D., Penninckx, S., Porcel, E., Prise, K. M., Rabus, H., Rudek, B., Sanche, L., Singh, B., Sokolov, K. V., Sridhar, S., Sung, W., Tillement, O., Virani, N., Yantasee, W., & Krishnan, S. (2020). Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Physics in Medicine and Biology, 65(21), 1–64. https://doi.org/10.1088/1361-6560/ab9159

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