| Zugriffsnummer | 44628 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Identifying biological markers for improved precision medicine in psychiatry |
| Autor(in); Institution |
Quinlan, E.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, G.; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Desrivières, S.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Frouin, V.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Brühl, Rüdiger; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Saclay, University Paris Descartes - Sorbonne Paris Cité; Maison de Solenn, Paris, FRANCE
Paillère Martinot, M.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud - Paris Saclay, University Paris Descartes; and AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation, Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College, Dublin, IRELAND
Schumann, G.; PONS Research Group, Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin and Leibniz Institute for Neurobiology, Magdeburg, GERMANY
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| Quelle/Jahr | Molecular Psychiatry: 25 (2020), 243 - 253 |
| ISSN | 1359-4184 (PRINT) ; 1476-5578 (ONLINE) |
| DOI | |
| Verlag | Basingstoke: Nature Publ. |
| Zusammenfassung | Mental disorders represent an increasing personal and financial burden and yet treatment development has stagnated in recent decades. Current disease classifications do not reflect psychobiological mechanisms of psychopathology, nor the complex interplay of genetic and environmental factors, likely contributing to this stagnation. Ten years ago, the longitudinal IMAGEN study was designed to comprehensively incorporate neuroimaging, genetics, and environmental factors to investigate the neural basis of reinforcement-related behavior in normal adolescent development and psychopathology. In this article, we describe how insights into the psychobiological mechanisms of clinically relevant symptoms obtained by innovative integrative methodologies applied in IMAGEN have informed our current and future research aims. These aims include the identification of symptom groups that are based on shared psychobiological mechanisms and the development of markers that predict disease course and treatment response in clinical groups. These improvements in precision medicine will be achieved, in part, by employing novel methodological tools that refine the biological systems we target. We will also implement our approach in low- and medium-income countries to understand how distinct environmental, socioeconomic, and cultural conditions influence the development of psychopathology. Together, IMAGEN and related initiatives strive to reduce the burden of mental disorders by developing precision medicine approaches globally. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Quinlan, E., Banaschewski, T., Barker, G., Bokde, A., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Heinz, A., Brühl, R., Martinot, J., Paillère Martinot, M., Nees, F., Orfanos, D., Paus, T., Poustka, L., Hohmann, S., Smolka, M., Fröhner, J., Walter, H., Whelan, R., & Schumann, G. (2020). Identifying biological markers for improved precision medicine in psychiatry. Molecular Psychiatry, 25, 243–253. https://doi.org/10.1038/s41380-019-0555-5