| Zugriffsnummer | 44582 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | ohne Peer Review |
| Sprache | Englisch |
| Titel | Electrolytes in human serum - two decades of SI traceability |
| Autor(in); Institution |
Rienitz, Olaf; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
Röhker, Karin; PTB-Braunschweig, formerly
Pape, Carola; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
Ulbrich, Silvia; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
Schulz, Ursula; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
Towara, Jessica; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
Görlitz, Volker; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
Jährling, Reinhard; PTB-Braunschweig, formerly
Röthke, Anita; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
Schiel, Detlef; PTB-Braunschweig, formerly
Stosch, Rainer; 3.1, Allgemeine und Anorganische Chemie, PTB-Braunschweig
|
| Quelle/Jahr | PTB-Mitteilungen: 130 (2020), 2, 23 - 30 |
| ISSN | 0030-834X |
| DOI | |
| Verlag | Braunschweig [u.a.]: Physikalisch-Technische Bundesanstalt |
| Zusammenfassung | The ions lithium, sodium, potassium, magnesium, calcium, and chloride are important constituents of the electrolytes in human serum. Since electrolytes play an important role in the human body, the concentrations of the above-mentioned ions in human serum are meaningful markers for several diseases. For this reason, PTB has developed pri-mary methods of measurement for the SI traceable determination of these ions in the past more than two decades, as well as a routine method based on ion chromatography. The equivalence of the results of the primary method on the one hand and the routine method on the other hand as well as the international comparability of the results was demonstrated through successful participation in CCQM key comparisons. As a consequence, PTB holds eight serum-related CMC claims in the according BIPM database. The routine method was continuously improved over time resulting in relative measurement uncertainties of less than 0.5 % nearly on par with the ones obtained with the primary methods. Important improvements discussed in this work are the optimization of the serum digestion, the gravimetric preparation of reference solutions starting from primary mono-elemental solutions, and the development of the exact matching one-point calibration as well as the combination of chemical and CO2-suppression. |
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Zitierung
Rienitz, O., Röhker, K., Pape, C., Ulbrich, S., Schulz, U., Towara, J., Görlitz, V., Jährling, R., Röthke, A., Schiel, D., & Stosch, R. (2020). Electrolytes in human serum - two decades of SI traceability. PTB-Mitteilungen, 130(2), 23–30. https://doi.org/10.7795/310.20200299