| Zugriffsnummer | 44572 |
| Dokumenttyp | Buchartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Fluorescence imaging of breast tumors and gastrointestinal cancer |
| Autor(in); Institution |
Grosenick, Dirk; 8.3, Biomedizinische Optik, PTB-Berlin
Bremer, Ch.; St. Franziskus Hospital GmbH, Münster, GERMANY
|
| Quelle/Jahr | Molecular Imaging in Oncology:(2020), 591 - 624 |
| Auflage | 2nd Edition |
| Schriftenreihe | Recent Results in Cancer Research: 216 |
| Herausgeber(in) |
Schober, Otmar
Kiessling, Fabian
Debus, Jürgen
|
| ISBN | 978-3-030-42617-0 (PRINT) ; 978-3-030-42618-7 (ONLINE) |
| DOI | |
| Verlag | Cham: Springer Nature Switzerland AG |
| Freie Schlagworte | Fluorescence imaging of cancer ; Optical molecular imaging ; Fluorescence-guided surgery ; Breast cancer ; Esophageal cancer ; Colon cancer ; Dysplasia |
| Zusammenfassung | Optical imaging offers a high potential for non-invasive detection and for therapy of cancer in humans. Recent advances in instrumentation for diffuse optical imaging have led to new capabilities for the detection of cancer in highly scattering tissue such as the female breast. In particular, fluorescence imaging was made applicable as a sensitive technique to image molecular probes in vivo. We review recent developments in the detection of breast cancer and in fluorescence-guided surgery of the breast by contrast agents available for application on humans. Detection of cancer has been investigated with the unspecific contrast agents indocyanine green and omocianine so far. Hereby, indocyanine green was found to offer high potential for the differentiation of malignant and benign lesions by exploiting vessel permeability for macromolecules as a cancer specific feature. Tumor specific molecular targeting and activatable probes have been investigated in first clinical trials for fluorescence-guided tumor margin detection. In this application high spatial resolution can be achieved, since tumor regions are visualized mainly at the tissue surface. As another example for superficial tumor tissue, imaging of lesions in the gastrointestinal tract is discussed. Promising results have been obtained on high risk patients with Barrett's esophagus and with ulcerative coli-tis by administering 5-aminolevulinic acid which induces accumulation of protoporphyrin IX serving as a tumor-specific fluorescent marker. Time-gated fluorescence imaging and spectroscopy are effective ways to suppress underlying background from tissue autofluorescence. Furthermore, recently developed tumor specific molecular probes have been demonstrated to be superior to white-light endoscopy offering new ways for early detection of malignancies in the gastrointestinal tract. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Grosenick, D. & Bremer, C. (2020). Fluorescence imaging of breast tumors and gastrointestinal cancer. In O. Schober, F. Kiessling, & J. Debus (Eds.), Molecular Imaging in Oncology (pp. 591–624). Cham: Springer Nature Switzerland AG. https://doi.org/10.1007/978-3-030-42618-7_18