| Zugriffsnummer | 44557 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Performance of measurands in time-domain optical brain imaging: depth selectivity versus contrast-to-noise ratio |
| Autor(in); Institution |
Sudakou, Aleh; Nalecz Institute of Biocybernetics and Biomedical Engineering, Warsaw, POLAND
Yang, Lin; 8.3, Biomedizinische Optik, PTB-Berlin
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Wojtkiewicz, Stanislaw; Nalecz Institute of Biocybernetics and Biomedical Engineering, Warsaw, POLAND
Liebert, Adam; Nalecz Institute of Biocybernetics and Biomedical Engineering, Warsaw, POLAND
|
| Quelle/Jahr | Biomedical Optics Express: 11 (2020), 8, 4348 - 4365 |
| Availability | [online only] |
| ISSN | 2156-7085 (ONLINE) |
| DOI | |
| Verlag | Washington D.C.: Optical Society (OSA) |
| Freie Schlagworte | fNIRS ; functional near-infrared spectroscopy ; time domain ; brain imaging ; data analysis ; perturbation simulations ; moments ; time windows ; depth selectivity |
| Zusammenfassung | Time-domain optical brain imaging techniques introduce a number of different measurands for analyzing absorption changes located deep in the tissue, complicated by superficial absorption changes and noise. We implement a method that allows analysis, quantitative comparison and performance ranking of measurands under various conditions – including different values of reduced scattering coefficient, thickness of the superficial layer, and source-detector separation. Liquid phantom measurements and Monte Carlo simulations were carried out in two-layered geometry to acquire distributions of times of flight of photons and to calculate the total photon count, mean time of flight, variance, photon counts in time windows and ratios of photon counts in different time windows. Quantitative comparison of performance was based on objective metrics: relative contrast, contrast-to-noise ratio (CNR) and depth selectivity. Moreover, the product of CNR and depth selectivity was used to rank the overall performance and to determine the optimal source-detector separation for each measurand. Variance ranks the highest under all considered conditions. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Forschungsprojekt | Brain injury and trauma monitoring using advanced photonics - BitMap |
| Förderinformationen (1) |
Förderername: European Commission (EC)
Förderer ID: 0000 0001 2242 8989 Förderprogramm: H2020-MSCA-ITN-2015 Titel der Förderung: Brain injury and trauma monitoring using advanced photonics - BitMap Förderungsnummer: 675332 URI der Förderung: https://cordis.europa.eu/project/rcn/198508_en.html |
Zitierung
Sudakou, A., Yang, L., Wabnitz, H., Wojtkiewicz, S., & Liebert, A. (2020). Performance of measurands in time-domain optical brain imaging: depth selectivity versus contrast-to-noise ratio. Biomedical Optics Express, 11(8), 4348–4365. https://doi.org/10.1364/boe.397483