| Zugriffsnummer | 44387 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Metabolite cycled liver 1H MRS on a 7T parallel transmit system |
| Autor(in); Institution |
Xavier, A.; Department of Radiology, Imaging Division, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
de Castro, C.; Department of Radiology, Imaging Division, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Andia, M.; Biomedical Imaging Center, Pontificia, Universidad Católica de Chile, Santiago, CHILE
Luijten, P.; Department of Radiology, Imaging Division, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Klomp, D.; Department of Radiology, Imaging Division, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Fillmer, Ariane; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Prompers, J.; Department of Radiology, Imaging Division, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
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| Quelle/Jahr | NMR in Biomedicine:(2020), 14 S. |
| Availability | [online only] |
| ISSN | 1099-1492 |
| DOI | |
| Verlag | New York, NY: Wiley |
| Zusammenfassung | Introduction: Single-voxel 1H MRS in body applications often suffers from respiratory and other motion induced phase and frequency shifts, which lead to incoherent averaging and hence to suboptimal results. Methods: Here we show the application of metabolite cycling (MC) for liver STEAM-localized 1H MRS on a 7 T parallel transmit system, using eight transmit-receive fractionated dipole antennas with 16 additional, integrated receive loops. MC-STEAM measurements were made in six healthy, lean subjects and compared with STEAM measurements using VAPOR water suppression. Measurements were performed during free breathing and during synchronized breathing, for which the subjects did breathe in between the MRS acquisitions. Both intra-session repeatability and intersession reproducibility of liver lipid quantification with MC-STEAM and VAPOR-STEAM were determined. Results: The preserved water signal in MC-STEAM allowed for robust phase and frequency correction of individual acquisitions before averaging, which resulted in in vivo liver spectra that were of equal quality when measurements were made with free breathing or synchronized breathing. Intra-session repeatability and inter-session reproducibility of liver lipid quantification were better for MC-STEAM than for VAPOR-STEAM. This may also be explained by the more robust phase and frequency correction of the individual MC-STEAM acquisitions as compared with the VAPOR-STEAM acquisitions, for which the low-signal-to-noise ratio lipid signals had to be used for the corrections. Conclusion: Non-water-suppressed MC-STEAM on a 7 T system with parallel transmit is a promising approach for 1H MRS applications in the body that are affected by motion, such as in the liver, and yields better repeatability and reproducibility compared with water-suppressed measurements. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)
Förderungsnummer: Award Number 040.11.634 |