| Zugriffsnummer | 44378 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Diffusion-weighted renal MRI at 9.4 Tesla using RARE to improve anatomical integrity |
| Autor(in); Institution |
Periquito, J.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
Paul, K.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
Huelnhagen, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
Ku, M.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
Ji, Y.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
Cantow, K.; Institut für vegetative Physiologie, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Gladytz, Thomas; 8.3, Biomedizinische Optik, PTB-Berlin
Grosenick, Dirk; 8.3, Biomedizinische Optik, PTB-Berlin
Flemming, B.; Institut für vegetative Physiologie, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Seeliger, E.; Institut für vegetative Physiologie, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Waiczies, S.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
Niendorf, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
Pohlmann, A.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY
|
| Quelle/Jahr | Scientific Reports: 9 (2019), 12 S. |
| Artikelnummer | 19723 |
| Availability | [online-only] |
| ISSN | 2045-2322 |
| DOI | |
| Verlag | London: Nature Publishing Group |
| Freie Schlagworte | MRI ; Diffusion-weighted imaging ; Kidney disease |
| Zusammenfassung | Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive imaging technique sensitive to tissue water movement. By enabling a discrimination between tissue properties without the need of contrast agent administration, DWI is invaluable for probing tissue microstructure in kidney diseases. DWI studies commonly make use of single-shot Echo-Planar Imaging (ss-EPI) techniques that are prone to suffering from geometric distortion. The goal of the present study was to develop a robust DWI technique tailored for preclinical magnetic resonance imaging (MRI) studies that is free of distortion and sensitive to detect microstructural changes. Since fast spin-echo imaging techniques are less susceptible to B0 inhomogeneity related image distortions, we introduced a diffusion sensitization to a split-echo Rapid Acquisition with Relaxation Enhancement (RARE) technique for high field preclinical DWI at 9.4 T. Validation studies in standard liquids provided diffusion coefficients consistent with reported values from the literature. Split-echo RARE outperformed conventional ss-EPI, with ss-EPI showing a 3.5-times larger border displacement (2.60 vs. 0.75) and a 60% higher intra-subject variability (cortex = 74%, outer medulla = 62% and inner medulla = 44%). The anatomical integrity provided by the split-echo RARE DWI technique is an essential component of parametric imaging on the way towards robust renal tissue characterization, especially during kidney disease. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Titel der Förderung: SFB 1365 Förderungsnummer: 394046635 |
Zitierung
Periquito, J., Paul, K., Huelnhagen, T., Ku, M., Ji, Y., Cantow, K., Gladytz, T., Grosenick, D., Flemming, B., Seeliger, E., Waiczies, S., Niendorf, T., & Pohlmann, A. (2019). Diffusion-weighted renal MRI at 9.4 Tesla using RARE to improve anatomical integrity. Scientific Reports, 9, 12 S. https://doi.org/10.1038/s41598-019-56184-6