| Zugriffsnummer | 44248 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Neurobehavioural characterisation and stratification of reinforcement-related behaviour |
| Autor(in); Institution |
Jia, Tianye; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, CHINA
Ing, Alex; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, UK
Quinlan, Erin; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, UK
Tay, Nicole; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, UK
Luo, Qiang; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, UK
Francesca, Biondo; State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, CHINA
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, Gareth; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Bokde, Arun; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Bromberg, Uli; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, Christian; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Desrivières, Sylvane; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, UK
Feng, Jianfeng; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London, London, UK
Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Grigis, Antoine; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry”, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette, FRANCE
Martinot , Marie-Laure; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry”, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette, FRANCE
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, Tomáš; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Fröhner, Juliane; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY
Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, Gunter; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, CHINA
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| Quelle/Jahr | Nature Human Behaviour:(2020), 544 - 566 |
| Availability | [online-only] |
| ISSN | 2397-3374 |
| DOI | |
| Verlag | London: Nature Research |
| Zusammenfassung | Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social–emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Jia, T., Ing, A., Quinlan, E., Tay, N., Luo, Q., Francesca, B., Banaschewski, T., Barker, G., Bokde, A., Bromberg, U., Büchel, C., Desrivières, S., Feng, J., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Martinot , M.-L., Nees, F., Orfanos, D., Paus, T., Poustka, L., Fröhner, J., Smolka, M., Walter, H., Whelan, R., & Schumann, G. (2020). Neurobehavioural characterisation and stratification of reinforcement-related behaviour. Nature Human Behaviour, 544–566. https://doi.org/10.1038/s41562-020-0846-5