| Zugriffsnummer | 44202 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES) |
| Autor(in); Institution |
Captur, Gabriella; UCL Medical School, University College London, Bloomsbury Campus, London, UK
Bhandari, Abhiyan; UCL Medical School, University College London, Bloomsbury Campus, London, UK
Brühl, Rüdiger; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Keenan, Kathryn; National Institute of Standards and Technology (NIST), Boulder, CO, USA
Yang, Ye; Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, CHINA
Eames, Richard; Department of Physics, Imperial College London, London, UK
Benedetti, Giulia; Department of Radiology, Guys and St Thomas NHS Foundation Trust, London, UK
Torlasco, Camilla; University of Milan-Bicocca, Milan, ITALY
Ricketts, Lewis; UCL Medical School, University College London, Bloomsbury Campus, London, UK
Boubertakh, Redha; Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
Fatih, Nasri; UCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK
Greenwood, John; Multidisciplinary Cardiovascular Research Center & Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
Paulis, Leonie; Department of Radiology & Nuclear Medicine, Maastricht University Medical Centre, Maastricht, THE NETHERLANDS
Lawton, Chris; Bristol Heart Institute, National Institute of Health Research (NIHR) Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK
Bucciarelli-Ducci, Chiara; Bristol Heart Institute, National Institute of Health Research (NIHR) Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK
Lamb, Hildo; Department of Radiology, Leiden University Medical Centre, Leiden, THE NETHERLANDS
Steeds, Richard; University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham, UK
Leung, Steve; UK Albert B. Chandler Hospital - Pavilion G, Gill Heart & Vascular Institute, USA
Berry, Colin; Institute of Cardiovascular and Medical Sciences, Glasgow, Scotland, UK
Valentin, Sinitsyn; Department of Multidisciplinary Clinical Studies, Lomonosov Moscow State University, Moscow, RUSSIA
Flett, Andrew; University Hospital Southampton Foundation Trust, Tremona Road, Southampton, Hampshire, UK
de Lange, Charlotte; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, NORWAY
DeCobelli, Francesco; San Raffaele Hospital, Milan, ITALY
Viallon, Magalie; INSA, CNRS UMR 5520, INSERM U1206, University of Lyon, UJM-Saint-Etienne, CREATIS, Saint-Etienne, FRANCE
Croisille, Pierre; Department of Radiology, University Hospital Saint-Etienne, Saint-Etienne, FRANCE
Higgins, David; Philips, Philips Centre, Unit 3, Guildford Business Park, Guildford, Surrey, UK
Greiser, Andreas; SiemensHealthcare GmbH, Erlangen, GERMANY
Pang, Wenjie; Resonance Health, Claremont, AUSTRALIA
Hamilton-Craig, Christian; The Prince Charles Hospital, Griffith University and University of Queensland, Brisbane, AUSTRALIA
Strugnell, Wendy; The Prince Charles Hospital, Griffith University and University of Queensland, Brisbane, AUSTRALIA
Dresselaers, Tom; Department of Radiology, Universitair Ziekenhuis Leuven, Leuven, BELGIUM
Barison, Andrea; Fondazione Toscana Gabriele Monasterio, Pisa, ITALY
Dawson, Dana; School of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland, UK
Taylor, Andrew; Department of Medicine, Monash University, Melbourne, AUSTRALIA
Mongeon, François-Pierre; Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, QC, CANADA
Plein, Sven; Multidisciplinary Cardiovascular Research Center & Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, UK
Messroghli, Daniel; Department of Internal Medicine – Cardiology, Deutsches Herzzentrum Berlin, Berlin, GERMANY
Al-Mallah, Mouaz; King Abdulaziz Cardiac Center (KACC) (Riyadh), National Guard Health Affairs, Riyadh, KINGDOM OF SAUDI-ARABIA
Grieve, Stuart; The University of Sydney School of Medicine, Camperdown, AUSTRALIA
Lombardi, Massimo; I.R.C.C.S., Policlinico San Donato, San Donato Milanese, ITALY
Jang, Jihye; Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Cardiology East Campus, Boston, USA
Salerno, Michael; University of Virginia Health System, Charlottesville, VA, USA
Chaturvedi, Nish; UCL MRC Unit for Lifelong Health and Ageing, University College London, London, UK
Kellman, Peter; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Bluemke, David; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, USA
Nezafat, Reza; Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Cardiology East Campus, Boston, MA, USA
Gatehouse, Peter; CMRI Department, Royal Brompton Hospital, London, UK
Moon, James; Barts Heart Center, St Bartholomew’s Hospital, West Smithfield, London, UK
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| Quelle/Jahr | Journal of Cardiovascular Magnetic Resonance: 22 (2020), 31 |
| ISSN | 1097-6647 (PRINT) ; 1532-429X (ONLINE) |
| DOI | |
| Verlag | London: Biomed Central |
| Freie Schlagworte | T1 mapping ; Standardization ; Calibration ; Phantom ; Repeatability ; Extracellular volume |
| Zusammenfassung | Background: The T1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods: Phantoms batch-manufactured in August 2015 underwent 2years of structural imaging, B0 and B1, and“reference” slow T1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5T and 22 3T magnets using multiple T1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T1 variation. Results: Over 2years, phantom gel integrity remained intact (no rips/tears), B0 and B1 homogenous, and “reference” T1 stable compared to baseline (% change at 1.5T, 1.95±1.39%; 3T, 2.22±1.44%). Per degrees Celsius, 1.5T, T1 (MOLLI 5s(3s)3s) increased by 11.4ms in long native blood tubes and decreased by 1.2ms in short post-contrast myocardium tubes. Agreement of estimated T1 times with “reference” T1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R2 ranges for both field strengths, 0.99–1.00). Over 1year, many 1.5T and 3T sequences/magnets were repeatable with mean CoVs (1 and 2% respectively. Repeatability was narrower for 1.5T over 3T. Within T1MES repeatability for native T1 was narrow for several sequences, for example, at 1.5T, Siemens MOLLI 5s(3s)3s prototype number 448B (mean CoV=0.27%) and Philips modified Look-Locker inversion recovery (MOLLI) 3s(3s)5s (CoV 0.54%), and at 3T, Philips MOLLI 3b(3s)5b (CoV 0.33%) and Siemens shortened MOLLI (ShMOLLI) prototype 780C (CoV 0.69%). After adjusting for temperature and field strength, it was found that the T1 mapping sequence and scanner software version (both P(0.001at 1.5T and 3T), and to a lesser extent the scanner model (P=0.011, 1.5T only), had the greatest influence on T1 across multiple centers. Conclusion: The T1MES CE/FDA approved phantom is a robust quality assurance device. In a multi-center setting, T1 mapping had performance differences between field strengths, sequences, scanner software versions, and manufacturers. However, several specific combinations of field strength, sequence, and scanner are highly repeatable, and thus, have potential to provide standardized assessment of T1 times for clinical use, although temperature correction is required for native T1 tubes at least. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Captur, G., Bhandari, A., Brühl, R., Ittermann, B., Keenan, K., Yang, Y., Eames, R., Benedetti, G., Torlasco, C., Ricketts, L., Boubertakh, R., Fatih, N., Greenwood, J., Paulis, L., Lawton, C., Bucciarelli-Ducci, C., Lamb, H., Steeds, R., Leung, S., Berry, C., Valentin, S., Flett, A., de Lange, C., DeCobelli, F., Viallon, M., Croisille, P., Higgins, D., Greiser, A., Pang, W., Hamilton-Craig, C., Strugnell, W., Dresselaers, T., Barison, A., Dawson, D., Taylor, A., Mongeon, F.-P., Plein, S., Messroghli, D., Al-Mallah, M., Grieve, S., Lombardi, M., Jang, J., Salerno, M., Chaturvedi, N., Kellman, P., Bluemke, D., Nezafat, R., Gatehouse, P., & Moon, J. (2020). T1 mapping performance and measurement repeatability: results from the multi-national T1 mapping standardization phantom program (T1MES). Journal of Cardiovascular Magnetic Resonance, 22, 31. https://doi.org/10.1186/s12968-020-00613-3