Identification of neurobehavioural symptom groups based on shared brain mechanisms

Ing, Alex; Sämann, Philipp; Chu, Congying; Tay, Nicole; Biondo, Francesca; Robert, Gabriel; Jia, Tianye; Wolfers, Thomas; Desrivières, Sylvane; Banaschewski, Tobias; Bokde, Arun; Bromberg, Uli; Christian, Büchel; Conrod, Patricia; Fadai, Tahmine; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Spechler, Philip; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Ittermann, Bernd; Kappel, Viola; Martinot, Jean-Luc; Meyer-Lindenberg, Andreas; Millenet, Sabina; Nees, Frauke; van Noort, Betteke; Orfanos, Dimitri; Martinot, Marie-Laure; Penttilä, Jani; Poustka, Luise; Quinlan , Erin; Smolka, Michael; Stringaris, Argyris; Struve, Maren; Veer, Ilya; Walter, Henrik; Whelan, Robert; Andreassen, Ole; Agartz, Ingrid; Lemaitre, Hervé; Barker, Edward; Ashburner, John; Binder, Elisabeth; Buitelaar, Jan; Marquand, Andre; Robbins, Trevor; Schumann, Gunter; IMAGEN Consortium

doi:https://doi.org/10.1038/s41562-019-0738-8

Zugriffsnummer	43772
Dokumenttyp	Zeitschriftenartikel
Peer Review	mit Peer Review
Sprache	Englisch
Titel	Identification of neurobehavioural symptom groups based on shared brain mechanisms
Autor(in); Institution	Ing, Alex; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Sämann, Philipp; Neuroimaging, Max Planck Institute of Psychiatry, Munich, GERMANY Chu, Congying; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Tay, Nicole; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Biondo, Francesca; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Robert, Gabriel; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Jia, Tianye; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Wolfers, Thomas; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Njmegen, THE NETHERLANDS Desrivières, Sylvane; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Bokde, Arun; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND Bromberg, Uli; Systems Neuroscience, University Medical Centre Hamburg, Hamburg, GERMANY Christian, Büchel; Systems Neuroscience, University Medical Centre Hamburg, Hamburg, GERMANY Conrod, Patricia; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience King’s College London, London, UK Fadai, Tahmine; Systems Neuroscience, University Medical Centre Hamburg, Hamburg, GERMANY Flor, Herta; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Frouin, Vincent; NeuroSpin, CEA, Université Paris, Gif-sur-Yvette, FRANCE Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA Spechler, Philip; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK Grimmer, Yvonne; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Heinz, Andreas; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin Kappel, Viola; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Humboldt University, Berlin, GERMANY Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes, DIgiteo-Labs, Gif-sur-Yvette, and Maison de Solenn, Paris, FRANCE Meyer-Lindenberg, Andreas; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Millenet, Sabina; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY van Noort, Betteke; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Humboldt University, Berlin, GERMANY Orfanos, Dimitri; NeuroSpin, CEA, Université Paris, Gif-sur-Yvette, FRANCE Martinot, Marie-Laure; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-surYvette, FRANCE Penttilä, Jani; Department of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic, Lahti, FINLAND Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY Quinlan , Erin; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Smolka, Michael; Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, GERMANY Stringaris, Argyris; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK Struve, Maren; Department of Psychiatry and Neuroimaging Centre, Technische Universität Dresden, Dresden, GERMANY Veer, Ilya; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY Walter, Henrik; Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GERMANY Whelan, Robert; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND Andreassen, Ole; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NORWAY Agartz, Ingrid; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NORWAY Lemaitre, Hervé; Institut National de la Santé et de la Recherche Médicale, UMR 992 INSERM, CEA, Faculté de médecine, Université Paris-Sud, Université Paris-Saclay, NeuroSpin, Gif-sur-Yvette, FRANCE Barker, Edward; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK Ashburner, John; Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, London, UK Binder, Elisabeth; Neuroimaging, Max Planck Institute of Psychiatry, Munich, GERMANY Buitelaar, Jan; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Njmegen, THE NETHERLANDS Marquand, Andre; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Njmegen, THE NETHERLANDS Robbins, Trevor; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK Schumann, Gunter; Centre for Population Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK IMAGEN Consortium,
Quelle/Jahr	Nature Human Behaviour: 3 (2019), 1306 - 1318
Availability	[online only]
ISSN	2397-3374
DOI	https://doi.org/10.1038/s41562-019-0738-8
Verlag	Berlin: Springer Nature
Zusammenfassung	Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

Themenbereich der Metrologie

Metrologie in der Medizin

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Ing, A., Sämann, P., Chu, C., Tay, N., Biondo, F., Robert, G., Jia, T., Wolfers, T., Desrivières, S., Banaschewski, T., Bokde, A., Bromberg, U., Christian, B., Conrod, P., Fadai, T., Flor, H., Frouin, V., Garavan, H., Spechler, P., Gowland, P., Grimmer, Y., Heinz, A., Ittermann, B., Kappel, V., Martinot, J.-L., Meyer-Lindenberg, A., Millenet, S., Nees, F., van Noort, B., Orfanos, D., Martinot, M.-L., Penttilä, J., Poustka, L., Quinlan , E., Smolka, M., Stringaris, A., Struve, M., Veer, I., Walter, H., Whelan, R., Andreassen, O., Agartz, I., Lemaitre, H., Barker, E., Ashburner, J., Binder, E., Buitelaar, J., Marquand, A., Robbins, T., Schumann, G., & IMAGEN Consortium. (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour, 3, 1306–1318. https://doi.org/10.1038/s41562-019-0738-8

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