| Zugriffsnummer | 43764 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group |
| Autor(in); Institution |
Jia, Tianye; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Papastergios, Evangelos; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Ruggeri, Barbara; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Quinlan, Erin; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Schumann, Gunter; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Desrivières, Sylvane; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
Liu, Yun; MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhongshan Hospital, Fudan University, Shanghai, CHINA
van Dongen, Jenny; Vrije Universiteit, Amsterdam, Dept Biological Psychology, Amsterdam, THE NETHERLANDS
den Braber, Anouk; Vrije Universiteit, Amsterdam, Dept Biological Psychology, Amsterdam, THE NETHERLANDS
van’t Ent, Dennis; Vrije Universiteit, Amsterdam, Dept Biological Psychology, Amsterdam, THE NETHERLANDS
Boomsma, Dorret; Vrije Universiteit, Amsterdam, Dept Biological Psychology, Amsterdam, THE NETHERLANDS
Armstrong, Nicola; Mathematics and Statistics, Murdoch University, Perth, WA, AUSTRALIA
Bastin, Mark; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, and Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh (MEB), Edinburgh, UK
Carrillo-Roa, Tania; Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, GERMANY
Sämann, Philipp; Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, GERMANY
Binder, Elisabeth; Department of Translational Research in Psychiatry, Max-Planck Institute of Psychiatry, Munich, GERMANY
Harris, Mathew; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK
Jansen, Rick; Department of Psychiatry, VU University Medical Centre, Amsterdam, THE NETHERLANDS
Liu, Jingyu; Department of Electrical Engineering, University of New Mexico, Albuquerque, NM, USA
Calhoun, Vince; Department of Electrical Engineering, University of New Mexico, Albuquerque, NM, USA
Luciano, Michelle; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
Deary, Ian; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
Ori, Anil; UCLA Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA
Teeuw, Jalmar; UCLA Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA
Santiañez, Roberto; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Santander, SPAIN
Gutiérrez, Diana; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Santander, SPAIN
Crespo-Facorro, Benedicto; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Santander, SPAIN
Sarkisyan, Daniil; Uppsala biomedicinska centrum BMC, Uppsala, SWEDEN
Bakalkin, Georgy; Uppsala biomedicinska centrum BMC, Uppsala, SWEDEN
Shin, Jean; Hospital for Sick Children, University of Toronto, Toronto, ON, CANADA
Pausova, Zdenka; Hospital for Sick Children, University of Toronto, Toronto, ON, CANADA
Sungeun, Kim; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
Ames, David; National Ageing Research Institute, Parkville, VIC, AUSTRALIA
Artiges, Eric; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud-Paris Saclay, University Paris Descartes, Orsay, FRANCE
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud-Paris Saclay, University Paris Descartes, Orsay, FRANCE
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY
Nees, Frauke; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, GERMANY
Bokde, Arun; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Brodaty, Henry; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AUSTRALIA
Jiang, Jiyang; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AUSTRALIA
Mather, Karen; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AUSTRALIA
Thalamuthu, Anbupalam; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AUSTRALIA
Trollor, Julian; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AUSTRALIA
Wen, Wei; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AUSTRALIA
Sachdev, Perminder; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AUSTRALIA
Bromberg, Uli; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, Christian; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Brouwer, Rachel; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Cahn, Wiepke; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Teeuw, Jalmar; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Pol, Hilleke; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
Ophoff, Roel; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, THE NETHERLANDS
de Zubicaray, Greig; Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AUSTRALIA
Ehrlich, Stefan; Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, GERMANY
Ekström, Tomas; Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, SWEDEN
Flor, Herta; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Fröhner, Juliane; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Smolka, Michael; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Frouin, Vincent; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Orfanos, Dimitri; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, Andreas; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GERMANY
Walter, Henrik; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GERMANY
Jacqueline, Hoare; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, SOUTH AFRICA
Dan, Stein; Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, SOUTH AFRICA
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Jahanshad, Neda; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA
Thompson, Paul; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA
Kwok, John; Central Clinical School—Brain and Mind Centre, The University of Sydney, Camperdown, AUSTRALIA
Martin, Nicholas; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, AUSTRALIA
Margaret, Wright; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, AUSTRALIA
Jean-Luc, Martinot; Maison de Solenn, Cochin Hospital, Paris, FRANCE
Schofield, Peter; Neuroscience Research Australia, Sydney, AUSTRALIA
McMahon, Katie; Herston Imaging Research Facility, School of Clinical Sciences, Queensland University of Technology, Brisbane, AUSTRALIA
McRae, Allan; Institute for Molecular Bioscience, University of Queensland, Brisbane, AUSTRALIA
Paus, Tomáš; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, CANADA
Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Stein, Dan; SAMRC Unit on Risk & Resilience in Mental Disorders, Cape Town, SOUTH AFRICA
Strike, Lachlan; Queensland Brain Institute, University of Queensland, Brisbane, AUSTRALIA
|
| Quelle/Jahr | Molecular Psychiatry:(2019), 12 S. |
| Availability | [online first] |
| ISSN | 1359-4184 (PRINT) ; 1476-5578 (ONLINE) |
| DOI | |
| Verlag | Basingstoke: Nature Publ. |
| Zusammenfassung | DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions. |
| Kostenfreier Zugang | Open Access Hybrid |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Jia, T., Papastergios, E., Ruggeri, B., Quinlan, E., Schumann, G., Desrivières, S., Liu, Y., van Dongen, J., den Braber, A., van’t Ent, D., Boomsma, D., Armstrong, N., Bastin, M., Carrillo-Roa, T., Sämann, P., Binder, E., Harris, M., Jansen, R., Liu, J., Calhoun, V., Luciano, M., Deary, I., Ori, A., Teeuw, J., Santiañez, R., Gutiérrez, D., Crespo-Facorro, B., Sarkisyan, D., Bakalkin, G., Shin, J., Pausova, Z., Sungeun, K., Ames, D., Artiges, E., Martinot, J.-L., Banaschewski, T., Nees, F., Bokde, A., Brodaty, H., Jiang, J., Mather, K., Thalamuthu, A., Trollor, J., Wen, W., Sachdev, P., Bromberg, U., Büchel, C., Brouwer, R., Cahn, W., Teeuw, J., Pol, H., Ophoff, R., de Zubicaray, G., Ehrlich, S., Ekström, T., Flor, H., Fröhner, J., Smolka, M., Frouin, V., Orfanos, D., Garavan, H., Gowland, P., Heinz, A., Walter, H., Jacqueline, H., Dan, S., Ittermann, B., Jahanshad, N., Thompson, P., Kwok, J., Martin, N., Margaret, W., Jean-Luc, M., Schofield, P., McMahon, K., McRae, A., Paus, T., Poustka, L., Stein, D., & Strike, L. (2019). Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group. Molecular Psychiatry, 12 S. https://doi.org/10.1038/s41380-019-0605-z