| Zugriffsnummer | 43346 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Establishment of measurement traceability for peptide and protein quantification through rigorous purity assessment - a review |
| Autor(in); Institution |
Josephs, Ralf D.; Bureau International des Poids et Mesures (BIPM), Sevres, FRANCE
Martos, Gustavo; Bureau International des Poids et Mesures (BIPM), Sevres, FRANCE
Li, Ming; Bureau International des Poids et Mesures (BIPM), Sevres, FRANCE; National Institute of Metrology (NIM), Beijing, CHINA
Melanson, Jeremy E.; National Research Council Canada (NRC), Metrology, Ottawa, CANADA
Quaglia, Milena; LGC, Teddington, UK
Beltrão, Paulo J.; Instituto Nacional de Metrologia, Qualidade e Tecnologica (INMETRO), Duque de Caxias, BRAZIL
Prevoo-Franzsen, Désirée; National Metrology Institute of South Africa (NMISA), Pretoria, SOUTH AFRICA
Boeuf, Amandine; Laboratoire National de Metrologie et d'Essais (LNE), Paris, FRANCE
Delatour, Vincent; Laboratoire National de Metrologie et d'Essais (LNE), Paris, FRANCE
Öztug, Merve; National Institute of Metrology (TUBITAK UME), Gebze-Kocaeli, TURKEY
Henrion, André; 3.2, Biochemie, PTB-Braunschweig
Jeong, Ji-Seon; Korea Research Institute of Standards and Science (KRISS), Daejeon, REPUBLIC OF KOREA
Park, Sang-Ryoul; Korea Research Institute of Standards and Sciences (KRISS), Daejeon, REPUBLIC OF KOREA
|
| Quelle/Jahr | Metrologia: 56 (2019), 4, 1 - 29 |
| Artikelnummer | 044006 |
| ISSN | 0026-1394 (PRINT) ; 1681-7575 (ONLINE) |
| DOI | |
| Verlag | Bristol: IOP Publishing |
| Zusammenfassung | The health of their populations and efficient health care systems are of critical importance to the economic and social well-being of nations. Accurate and comparable peptide/protein measurements are required in support of diagnosis, prognosis, monitoring and treatment of widespread diseases (e.g. diabetes). The required consistency of measurement results can be achieved by making them traceable to stated references and through the development of Reference Measurement Systems. The review mainly concentrates on the progress made in the Protein Analysis Working Group of the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology (CCQM-PAWG) in establishing Primary Calibration Reference Services in the emerging area of health markers such as peptides/proteins. Primary Calibration Reference Services are technical capabilities for composition assignment, commonly as the mass fraction content, of pure substances or solutions thereof. It is a core technical competency for National Measurement Institutes (NMIs). A limited number of key comparisons, foreseen by the CCQM-PAWG strategy, are discussed that enable NMIs providing measurement services in peptide/protein analysis to test and demonstrate their capabilities. In addition, the review examines the development and improvement of analytical methods and metrological models that are required to meet the needs of NMIs and associated clinical stakeholders. |
Zitierung
Josephs, R. D., Martos, G., Li, M., Melanson, J. E., Quaglia, M., Beltrão, P. J., Prevoo-Franzsen, D., Boeuf, A., Delatour, V., Öztug, M., Henrion, A., Jeong, J.-S., & Park, S.-R. (2019). Establishment of measurement traceability for peptide and protein quantification through rigorous purity assessment - a review. Metrologia, 56(4), 1–29. https://doi.org/10.1088/1681-7575/ab27e5