| Zugriffsnummer | 43220 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Grey matter volume differences associated with extremely low levels of cannabis use in adolescence |
| Autor(in); Institution |
Orr, C.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Spechler, P.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Cao, Z.; Department of Psychology, University College Dublin, IRELAND
Albaugh, M.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Chaarani, B.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Mackey, S.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
D'Souza, D.; Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA
Allgaier, N.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Burke Quinlan, E.; Centre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Conrod, P.; National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, Addiction Sciences Building, London, UK
Desrivières, S.; Centre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Flor, H.; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Frouin, V.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging and Psychiatry", University Paris Sud-University Paris Saclay, DIGITEO Labs, Gif sur Yvette, FRANCE
Martinot, M.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging and Psychiatry", and AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FRANCE
Paus, T.; Rotman Research Institute, Baycrest, and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY
Millenet, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Fröhner, J.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Radhakrishnan, R.; Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; Department of Psychology, University College Dublin, Dublin, IRELAND
Schumann, G.; Centre for Population Neuroscience and Stratified Medicine (PONS) and MRC-SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Potter, A.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
|
| Quelle/Jahr | The Journal of Neuroscience: 39 (2019), 10, 1817 - 1827 |
| ISSN | 0270-6474 (PRINT) ; 1529-2401 (ONLINE) |
| DOI | |
| Verlag | Washington, DC: Society for Neuroscience |
| Freie Schlagworte | adolescent substance use ; cannabis ; cognition ; marijuana ; psychopathology ; voxel-based morphometry |
| Zusammenfassung | Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current study, we used voxel-based morphometry to compare gray matter volume (GMV) in forty-six 14-year-old human adolescents (males and females) with just one or two instances of cannabis use and carefully matched THC-naive controls. We identified extensive regions in the bilateral medial temporal lobes as well as the bilateral posterior cingulate, lingual gyri, and cerebellum that showed greater GMV in the cannabis users. Analysis of longitudinal data confirmed that GMV differences were unlikely to precede cannabis use. GMV in the temporal regions was associated with contemporaneous performance on the Perceptual Reasoning Index and with future generalized anxiety symptoms in the cannabis users. The distribution of GMV effects mapped onto biomarkers of the endogenous cannabinoid system providing insight into possible mechanisms for these effects.SIGNIFICANCE STATEMENT Almost 35% of American 10th graders have reported using cannabis and existing research suggests that initiation of cannabis use in adolescence is associated with long-term neurocognitive effects. We understand very little about the earliest effects of cannabis use, however, because most research is conducted in adults with a heavy pattern of lifetime use. This study presents evidence suggesting structural brain and cognitive effects of just one or two instances of cannabis use in adolescence. Converging evidence suggests a role for the endocannabinoid system in these effects. This research is particularly timely as the legal status of cannabis is changing in many jurisdictions and the perceived risk by youth associated with smoking cannabis has declined in recent years. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Orr, C., Spechler, P., Cao, Z., Albaugh, M., Chaarani, B., Mackey, S., D'Souza, D., Allgaier, N., Banaschewski, T., Bokde, A., Bromberg, U., Büchel, C., Burke Quinlan, E., Conrod, P., Desrivières, S., Flor, H., Frouin, V., Gowland, P., Heinz, A., Ittermann, B., Martinot, J., Martinot, M., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Millenet, S., Fröhner, J., Radhakrishnan, R., Smolka, M., Walter, H., Whelan, R., Schumann, G., Potter, A., & Garavan, H. (2019). Grey matter volume differences associated with extremely low levels of cannabis use in adolescence. The Journal of Neuroscience, 39(10), 1817–1827. https://doi.org/10.1523/jneurosci.3375-17.2018