| Zugriffsnummer | 41986 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | What roles for track-structure and microdosimetry in the era of -omics and systems biology? |
| Autor(in); Institution |
Baiocco, G.; University of Pavia, Physics Department, Pavia, ITALY
Babini, G.; University of Pavia, Physics Department, Pavia, ITALY
Barbieri, S.; University of Pavia, Physics Department, Pavia, ITALY
Morini, J.; University of Pavia, Physics Department, Pavia, ITALY
Friedland, W.; Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Institute of Radiation Protection, Neuherberg, GERMANY
Villagrasa, C.; Institut de Radioprotection et de Sûreté Nucléaire, Fontenay aux Roses, FRANCE
Rabus, Hans; 6.5, Strahlenwirkung, PTB-Braunschweig
Ottolenghi, A.; University of Pavia, Physics Department, Pavia, ITALY
|
| Quelle/Jahr | Radiation Protection Dosimetry: 183 (2018), 1-2, 22 - 25 |
| ISSN | 0144-8420 (PRINT) ; 1742-3406 (ONLINE) |
| DOI | |
| Verlag | Oxford: Oxford University Press |
| Konferenzangaben | 17th International Symposium on Microdosimetry, Venice, 05-10, November, 2017, Italy |
| Freie Schlagworte | Microdosimetry ; nanodosimetry ; track structure ; radiobiology |
| Zusammenfassung | Ionizing radiation is a peculiar perturbation when it comes to damage to biological systems: it proceeds through discrete energy depositions, over a short temporal scale and a spatial scale critical for subcellular targets as DNA, whose damage complexity determines the outcome of the exposure. This lies at the basis of the success of track structure (and nanodosimetry) and microdosimetry in radiation biology. However, such reductionist approaches cannot account for the complex network of interactions regulating the overall response of the system to radiation, particularly when effects are manifest at the supracellular level and involve long times. Systems radiation biology is increasingly gaining ground, but the gap between reductionist and holistic approaches is becoming larger. This paper presents considerations on what roles track structure and microdosimetry can have in the attempt to fill this gap, and on how they can be further exploited to interpret radiobiological data and inform systemic approaches. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Ionisierende Strahlung |
Zitierung
Baiocco, G., Babini, G., Barbieri, S., Morini, J., Friedland, W., Villagrasa, C., Rabus, H., & Ottolenghi, A. (2018). What roles for track-structure and microdosimetry in the era of -omics and systems biology? Radiation Protection Dosimetry, 183(1-2), 22–25. https://doi.org/10.1093/rpd/ncy221