| Zugriffsnummer | 41524 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Long-term stable measurement phantoms for magnetic particle imaging |
| Autor(in); Institution |
Wöckel, L.; Institut für Biomedizinische Technik und Informatik, Technische Universität Ilmenau, Ilmenau, GERMANY
Wells, James; 8.2, Biosignale, PTB-Berlin
Kosch, Olaf; 8.2, Biosignale, PTB-Berlin
Lyer, S.; Department of Otorhinolaryngology, Head and Neck Surgery, Section for Experimental Oncology & Nanomedicine (SEON), University Hospital, Erlangen, GERMANY
Alexiou, C.; Department of Otorhinolaryngology, Head and Neck Surgery, Section for Experimental Oncology & Nanomedicine (SEON), University Hospital, Erlangen, GERMANY
Grüttner, C.; Micromod Partikeltechnologie GmbH, Rostock, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
Dutz, S.; Institut für Biomedizinische Technik und Informatik, Technische Universität Ilmenau, Ilmenau, GERMANY
|
| Quelle/Jahr | 12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2018. Journal of Magnetism and Magnetic Materials: 471 (2019), 1 - 7 |
| ISSN | 0304-8853 (PRINT) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Konferenzangaben | 12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2018, Copenhagen, 22-26, May, 2018, Denmark |
| Freie Schlagworte | Magnetic particle imaging ; Magnetic particle spectroscopy ; Magnetic nanoparticles ; Measurement phantoms |
| Zusammenfassung | Magnetic particle imaging (MPI) is a tomographic imaging method to determine the spatial distribution of magnetic nanoparticles (MNP) within a defined volume. To evaluate the imaging capabilities of existing MPI scanners, their sensitivity and image resolution limits have to be analyzed. Therefore, precisely defined structures (phantoms) with various tracer concentrations are required to enable comparative studies between existing MPI systems. To support the development of capable MPI phantoms, we developed a method to incorporate different commercially available MNP into a long-term stable synthetic polymer with an iron concentration of up to 200 mmol/l. The properties of each type of polymer matrix embedded MNP were tested by magnetic particle spectroscopy (MPS). For shaping the particle loaded polymer to a phantom, we used 3-D printed molds with a structure cross section of 2×2mm² The particle loads within the phantoms were then imaged using MPI. The particle-loaded polymer is very suitable for preparation of measurement phantoms that could be visualized by MPI. Repeated shore hardness and MPS measurements up to one year did not reveal any changes in the mechanical and magnetic properties of the used material. In conclusion, we developed long-term stable measurement phantoms for magnetic particle imaging. Further work will focus on more detailed particle loaded structures in phantoms and water based polymers with a more homogeneous particle distribution. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Förderungsnummer: DU1293/6-1 ; TR408/9-1 ; AL552/8-1 |
| Förderinformationen (2) |
Förderername: Bundesministerium für Bildung und Forschung (BMBF)
Förderer ID: 0000 0000 9090 0344 Förderer ID Typ: ISNI Förderprogramm: InnoProfile project “MAMUD” Förderungsnummer: 03IPT605X |
Zitierung
Wöckel, L., Wells, J., Kosch, O., Lyer, S., Alexiou, C., Grüttner, C., Wiekhorst, F., & Dutz, S. (2019). Long-term stable measurement phantoms for magnetic particle imaging. Journal of Magnetism and Magnetic Materials, 471, 1–7. https://doi.org/10.1016/j.jmmm.2018.09.012