| Zugriffsnummer | 41517 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Evaluation of a separate-receive coil by magnetic particle imaging of a solid phantom |
| Autor(in); Institution |
Kosch, Olaf; 8.2, Biosignale, PTB-Berlin
Paysen, Hendrik; 8.2, Biosignale, PTB-Berlin
Wells, James; 8.2, Biosignale, PTB-Berlin
Ptach, Felix; 8.2, Biosignale, PTB-Berlin
Franke, J.; Bruker BioSpin, Ettlingen, GERMANY
Wöckel, L.; Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Ilmenau, GERMANY
Dutz, S.; Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Ilmenau, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
|
| Quelle/Jahr | 12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2018. Journal of Magnetism and Magnetic Materials:(2018), 444 - 449 |
| ISSN | 0304-8853 (PRINT) ; 1873-4766 (ONLINE) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Konferenzangaben | 12th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2018, Copenhagen, 22-26, May, 2018, Denmark |
| Freie Schlagworte | Magnetic Particle Imaging (MPI) ; image resolution analysis ; long-term stable phantom ; separate receive coil ; magnetic nanoparticles |
| Zusammenfassung | To aid the optimization and development of Magnetic particle imaging (MPI), an accurate and translatable apparatus and a methodology for the characterisation of imaging quality are required. This requires magnetic nanoparticles (MNP) as imaging tracer for MPI measurements in a long-term stable, defined state, since MNP in liquid suspension might tend to change their magnetic properties over time, e.g. as a result of particle aggregation, sedimentation, or disintegration. To this end, we have developed solid phantoms containing freeze-dried perimag in mannitol for the comparison of resolution capabilities between different MPI scanners. Freeze drying of MNP was determined to be the optimal immobilisation method for maintaining the dynamic magnetic properties of MNP as compared with polymer or starch techniques. Freeze-drying preserves the particle distribution, preventing the particles from aggregation or precipitation. Two different types of phantoms were developed, one (cross shaped) to seek for artefacts within reconstructed images, and one (coil shaped) to test the resolution limit. The resolution limit is determined from the coil phantom by measuring the smallest resolvable gap between the two adjacent tracer regions. Our resolution phantom contained a 2 mm wide channel filled with tracer. By using this phantom, the imaging performance of the preclinical MPI system and a prototype gradiometric separate receive coil installed within the same MPI scanner was determined. We found 2.1-2.2 mm resolution limit using the conventional set-up and 0.5-0.6 mm for the separate receive coil resulting in an improvement by factor four. Additionally, the resolution dependency on the channel wide was tested by a second resolution phantom contained a 1 mm wide channel. The long-term stability of the phantoms will be continuously monitored and improved. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Förderprogramm: quantMPI: Establishment of quantitative Magnetic Particle Imaging (MPI) application oriented phantoms for preclinical investigations Förderungsnummer: TR 408/9 - 1 ; DU1293/6 - 1 |
| Förderinformationen (2) |
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Förderprogramm: AMPI: Magnetic particle imaging: Development and evaluation of no vel methodology for the assessment of the aorta in vivo in a small animal model of aortic aneurysms Förderungsnummer: SHA 1506/2 - 1 |
| Förderinformationen (3) |
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Förderprogramm: SPP 1681: Field Controlled Particle Matrix Interaction: Synthesis, Multi - Scale Modelling and Application of Magnetic Hybrid - Materials Förderungsnummer: WI 4230/1 - 3 |
Zitierung
Kosch, O., Paysen, H., Wells, J., Ptach, F., Franke, J., Wöckel, L., Dutz, S., & Wiekhorst, F. (2018). Evaluation of a separate-receive coil by magnetic particle imaging of a solid phantom. Journal of Magnetism and Magnetic Materials, 444–449. https://doi.org/10.1016/j.jmmm.2018.09.114