| Zugriffsnummer | 41478 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Optimization of iron oxide tracer synthesis for Magnetic Particle Imaging |
| Autor(in); Institution |
Ziemann, S.; MR and CT Contrast Media Research, Bayer AG, Berlin, GERMANY
Löwa, Norbert; 8.2, Biosignale, PTB-Berlin
Kosch, Olaf; 8.2, Biosignale, PTB-Berlin
Bajj, D.; University of British Columbia, Vancouver, CANADA
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
Schütz, G.; MR and CT Contrast Media Research, Bayer AG, Berlin, GERMANY
|
| Quelle/Jahr | Nanomaterials: 8 (2018), 4, 1 - 13 |
| Availability | [online only] |
| ISSN | 2079-4991 |
| DOI | |
| Verlag | Basel: MDPI |
| Freie Schlagworte | iron oxide tracer ; magnetic particle imaging (MPI) ; magnetic particle spectroscopy (MPS) ; superparamagnetic nanoparticles |
| Zusammenfassung | The optimization of iron oxide nanoparticles as tracers for magnetic particle imaging (MPI) alongside the development of data acquisition equipment and image reconstruction techniques is crucial for the required improvements in image resolution and sensitivity of MPI scanners. We present a large-scale water-based synthesis of multicore superparamagnetic iron oxide nanoparticles stabilized with dextran (MC-SPIONs). We also demonstrate the preparation of single core superparamagnetic iron oxide nanoparticles in organic media, subsequently coated with a poly(ethylene glycol) gallic acid polymer and phase transferred to water (SC-SPIONs). Our aim was to obtain long-term stable particles in aqueous media with high MPI performance. We found that the amplitude of the third harmonic measured by magnetic particle spectroscopy (MPS) at 10 mT is 2.3- and 5.8-fold higher than Resovist for the MC-SPIONs and SC-SPIONs, respectively, revealing excellent MPI potential as compared to other reported MPI tracer particle preparations. We show that the reconstructed MPI images of phantoms using optimized multicore and specifically single-core particles are superior to that of commercially available Resovist, which we utilize as a reference standard, as predicted by MPS. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Bundesministerium für Bildung und Forschung (BMBF)
Förderer ID: 0000 0000 9090 0344 Förderer ID Typ: ISNI Förderprogramm: MapIT Förderungsnummer: 13N11092 |