| Zugriffsnummer | 41428 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response |
| Autor(in); Institution |
Macare, Christine; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UNITED KINGDOM; King's College London, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Centre for Population Neuroscience and Precision Medicine (PONS), London, UNITED KINGDOM
Ducci, Fracesca; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UNITED KINGDOM; King's College London, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Centre for Population Neuroscience and Precision Medicine (PONS), London, UNITED KINGDOM; University of London, St George's, London, UNITED KINGDOM
Zhang, Yuning; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UNITED KINGDOM; King's College London, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Centre for Population Neuroscience and Precision Medicine (PONS), London, UNITED KINGDOM
Ruggeri, Barbara; King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UNITED KINGDOM; King's College London, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, MRC Social, Centre for Population Neuroscience and Precision Medicine (PONS), London, UNITED KINGDOM
Jia, Tianye; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for Population Neuroscience and Precision Medicine (PONS), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Fudan University, Institute of Science and Technology for Brain-Inspired Intelligence, Shanghai, CHINA
Kaakinen, Marika; Imperial College London, Department of Medicine, Section of Genomics of Common Disease, London, UNITED KINGDOM; Imperial College London, Centre for Pharmacology and Therapeutics, London, UNITED KINGDOM
Kalsi, Gursharan; Clinical Physics, Barts Health NHS Trust, The Royal London Hospital, London, UK
Charoen, Pimphen; UCL Institute of Health Informatics, University College, London, UK
Casoni, Filippo; Division of Neuroscience, San Raffaele Scientific Institute, Milan, ITALY
Peters, Jan; Intelligent Autonomous Systems Group, Department of Computer Science, Technische Universität Darmstadt, Darmstadt, GERMANY
Bromberg, Uli; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Hill, Matthew; Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
Buxton, Jessica; UCL Great Ormond Street Institute of Child Health, London, UK
Blakemore, Alexandra; Division of Diabetes, Endocrinology and Metabolism, Faculty of Medicine, Imperial College London, London, UK
Veijola, Juha; Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, FINLAND
Büchel, Christian; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, GERMANY
Bokde, Arun L.W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College, Dublin, IRELAND
Conrod, Patricia; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Flor, Herta; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Frouin, Vincent; NeuroSpin, Gif-sur-Yvette, Paris, FRANCE
Gallinat, Jürgen; Clinic for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Garavan, Hugh; Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, Vermont, USA
Gowland, Penny A.; Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, UK
Heinz, Andreas; Clinic for Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Lathrop, Mark; Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, CANADA
Martinot, Jean-Luc; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University Paris Sud - Paris Saclay, University Paris Descartes, Paris, FRANCE
Paus, Tomás; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Desrivières, Sylvane; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Munafò, Marcus; MRC Integrative Epidemiology Unit, UK Centre for Tobacco Control Studies and School of Experimental Psychology, University of Bristol, Bristol, UK
Järvelin, Marjo-Riitta; Institute of Health Sciences, University of Oulu, Oulu, FINLAND
Schumann, Gunter; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
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| Quelle/Jahr | European Neuropsychopharmacology: 28 (2018), 10, 1103 - 1114 |
| ISSN | 0924-977X (PRINT) ; 1873-7862 (ONLINE) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | fMRI ; Genetics ; IMAGEN-ALSPAC-NFBC ; Meta-analysis ; Risk taking ; Smoking |
| Zusammenfassung | The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10-4) and higher plasma cotinine levels (p = 7.0 × 10-5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY-NC-ND 4.0 ; Creative Commons Attribution NonCommercial NoDerivatives 4.0 License |
| Themenbereich der Metrologie | Metrologie in der Medizin |
Zitierung
Macare, C., Ducci, F., Zhang, Y., Ruggeri, B., Jia, T., Kaakinen, M., Kalsi, G., Charoen, P., Casoni, F., Peters, J., Bromberg, U., Hill, M., Buxton, J., Blakemore, A., Veijola, J., Büchel, C., Banaschewski, T., Bokde, A. L., Conrod, P., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P. A., Heinz, A., Ittermann, B., Lathrop, M., Martinot, J.-L., Paus, T., Desrivières, S., Munafò, M., Järvelin, M.-R., & Schumann, G. (2018). A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. European Neuropsychopharmacology, 28(10), 1103–1114. https://doi.org/10.1016/j.euroneuro.2018.07.101