| Zugriffsnummer | 40360 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Risk profiles for heavy drinking in adolescence: differential effects of gender |
| Autor(in); Institution |
Seo, S.; Neural Information Processing Group, Department of Computer Science and Electrical Engineering, Technische Universität Berlin, and Bernstein Center for Computational Neuroscience, GERMANY
Beck, A.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, GERMANY
Matthis, C.; Neural Information Processing Group, Department of Computer Science and Electrical Engineering, Technische Universität Berlin, and Bernstein Center for Computational Neuroscience, GERMANY
Genauck, A.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, GERMANY
Bokde, A. L. W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, IRELAND
Bromberg, U.; Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, GERMANY
Büchel, C.; Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, GERMANY
Quinlan, E.; Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, GERMANY
Frouin, V.; NeuroSpin, CEA, Université Paris-Saclay, FRANCE
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, UK
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 'Neuroimaging and Psychiatry', University Paris Sud-Paris Saclay, University Paris Descartes, Service Hospitalier Frédéric Joliot, Orsay and Maison de Solenn, FRANCE
Paillère Martinot, M.-L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 'Neuroimaging and Psychiatry', University Paris Sud-Paris Saclay, University Paris Descartes and AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Sole
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, GERMANY; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, GERMANY
Orfanos, D. P.; NeuroSpin, CEA, Université Paris-Saclay, FRANCE
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, GERMANY
Hohmann, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, GERMANY
Fröhner, J. H.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, GERMANY
Smolka, M. N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, IRELAND
Desrivères, S.; Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, GERMANY
Schumann, G.; Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK
Obermayer, K.; Neural Information Processing Group, Department of Computer Science and Electrical Engineering, Technische Universität Berlin, and Bernstein Center for Computational Neuroscience, GERMANY
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| Quelle/Jahr | Addiction Biology: 24 (2019), 4, 787 - 801 |
| ISSN | 1355-6215 (PRINT) ; 1369-1600 (ONLINE) |
| DOI | |
| Verlag | Oxford: Wiley-Blackwell |
| Freie Schlagworte | adolescence ; brain endophenotypes ; gender differences ; heavy drinking ; structural MRI |
| Zusammenfassung | Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk profiles is unclear, and it is further unclear whether these risk profiles differ between genders. We combined longitudinal and cross‐sectional analyses on the large IMAGEN sample (N ≈ 1000) to predict heavy drinking at age 19 from gray matter volume as well as from psychosocial data at age 14 and 19 - for males and females separately. Heavy drinking was associated with reduced gray matter volume in 19‐year‐olds' bilateral ACC, MPFC, thalamus, middle, medial and superior OFC as well as left amygdala and anterior insula and right inferior OFC. Notably, this lower gray matter volume associated with heavy drinking was stronger in females than in males. In both genders, we observed that impulsivity and facets of novelty seeking at the age of 14 and 19, as well as hopelessness at the age of 14, are risk factors for heavy drinking at the age of 19. Stressful life events with internal (but not external) locus of control were associated with heavy drinking only at age 19. Personality and stress assessment in adolescents may help to better target counseling and prevention programs. This might reduce heavy drinking in adolescents and hence reduce the risk of early brain atrophy, especially in females. In turn, this could additionally reduce the risk of developing alcohol use disorders later in adulthood. |
| Themenbereich der Metrologie | Metrologie in der Medizin |
| Förderinformationen (1) |
Förderername: Bundesministerium für Bildung und Forschung (BMBF)
Förderer ID: 0000 0000 9090 0344 Förderer ID Typ: ISNI Förderungsnummer: Grant Number: 01EV071101GS0815201ZX1311A01ZX1311D/E 01ZX1611D/E |
| Förderinformationen (2) |
Förderername: Deutsche Forschungsgemeinschaft (DFG)
Förderer ID: 0000 0001 2096 9829 Förderer ID Typ: ISNI Förderungsnummer: EXC 257 FOR 1617 GRK 1589/2 HE2597/14‐2SFB 940/1SM 80/7‐1SM 80/7‐2, SFB 940/1, SM 80/7‐2, SM 80/7‐1 |
Zitierung
Seo, S., Beck, A., Matthis, C., Genauck, A., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E., Flor, H., Frouin, V., Garavan, H., Gowland, P., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Nees, F., Orfanos, D. P., Poustka, L., Hohmann, S., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Desrivères, S., Heinz, A., Schumann, G., & Obermayer, K. (2019). Risk profiles for heavy drinking in adolescence: differential effects of gender. Addiction Biology, 24(4), 787–801. https://doi.org/10.1111/adb.12636