| Zugriffsnummer | 40289 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Individual differences in stop-related activity are inflated by the adaptive algorithm in the stop signal task |
| Autor(in); Institution |
D'Alberto, N.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Chaarani, B.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Orr, C. A.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Spechler, P. A.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Albaugh, M. D.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Allgaier, N.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Wonnell, A.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A. L. W.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College, Dublin, IRELAND
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Quinlan, E. B.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
Conrod, P. J.; Department of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, Montreal, Quebec, CANADA; Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Desriviéres, S.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, GERMANY
Fröhner, H. R.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Frouin, V.; Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, FRANCE
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J. L.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité and Maison de Solenn, Paris, FRANCE
Paillére Martinot, M. L.; Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité and Psychiatry, Paris, FRANCE
Artiges, E.; Orsay Hospital, Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité and Psychiatry, Paris, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos Orfanos, D.; Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, FRANCE
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, GERMANY; Clinic for Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, AUSTRIA
Robbins, T. W.; Department of Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Smolka, M. N.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
Potter, A. S.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
Garavan, H.; Department of Psychiatry, University of Vermont College of Medicine, Burlington, Vermont, USA
|
| Quelle/Jahr | Human Brain Mapping: 39 (2018), 8, 3263 - 3276 |
| ISSN | 1065-9471 (PRINT) ; 1097-0193 (ONLINE) |
| DOI | |
| Verlag | Wiley-Blackwell |
| Freie Schlagworte | objective task difficulty ; response inhibition ; stop signal delay |
| Zusammenfassung | Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show reduced neural activity in key inhibitory regions during successful stopping. However, the adaptive algorithm systematically introduces performance-related differences in objective task difficulty that may influence the estimation of individual differences in stop-related neural activity. This report examines the effect that these algorithm-related differences have on the measurement of neural activity during the stop signal task. We compared two groups of subjects (n = 210) who differed in inhibitory ability using both a standard fMRI analysis and an analysis that resampled trials to remove the objective task difficulty confound. The results show that objective task difficulty influences the magnitude of between-group differences and that controlling for difficulty attenuates stop-related activity differences between superior and poor inhibitors. Specifically, group differences in the right inferior frontal gyrus, right middle occipital gyrus, and left inferior frontal gyrus are diminished when differences in objective task difficulty are controlled for. Also, when objective task difficulty effects are exaggerated, group differences in stop related activity emerge in other regions of the stopping network. The implications of these effects for how we interpret individual differences in activity levels are discussed. |
| Förderinformationen (1) |
Förderername: European Union (EU)
Förderer ID: 0000 0001 2375 4495 Förderer ID Typ: ISNI Förderprogramm: FP6 Integrated Project IMAGEN (Reinforcement‐related behavior in normal brain function and psychopathology) Förderungsnummer: LSHM‐CT‐ 2007‐037286 |
Zitierung
D'Alberto, N., Chaarani, B., Orr, C. A., Spechler, P. A., Albaugh, M. D., Allgaier, N., Wonnell, A., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Conrod, P. J., Desriviéres, S., Flor, H., Fröhner, H. R., Frouin, V., Gowland, P., Heinz, A., Ittermann, B., Martinot, J. L., Paillére Martinot, M. L., Artiges, E., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Robbins, T. W., Smolka, M. N., Walter, H., Whelan, R., Schumann, G., Potter, A. S., & Garavan, H. (2018). Individual differences in stop-related activity are inflated by the adaptive algorithm in the stop signal task. Human Brain Mapping, 39(8), 3263–3276. https://doi.org/10.1002/hbm.24075