Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project

Winterer, G.; Androsova, G.; Bender, O.; Boraschi, D.; Borchers, F.; Dschietzig, T. B.; Feinkohl, I.; Fletcher, P.; Gallinat, J.; Hadzidiakos, D.; Haynes, J. D.; Heppner, F.; Hetzer, S.; Hendrikse, J.; Ittermann, Bernd; Kant, I. M J.; Kraft, A.; Krannich, A.; Krause, R.; Kühn, S.; Lachmann, G.; van Montfort, S. J. T.; Müller, A.; Nürnberg, P.; Ofosu, K.; Pietsch, M.; Pischon, T.; Preller, J.; Renzulli, E.; Scheurer, K.; Schneider, R.; Slooter, A. J. C.; Spies, C.; Stamatakis, E.; Volk, H. D.; Weber, S.; Wolf, A.; Yürek, F.; Zacharias, N.

doi:https://doi.org/10.1016/j.eurpsy.2017.10.004

Zugriffsnummer	40284
Dokumenttyp	Zeitschriftenartikel
Sprache	Englisch
Titel	Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project
Autor(in); Institution	Winterer, G.; Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; Pharmaimage Biomarker Solutions GmbH, Berlin, GERMANY Androsova, G.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, LUXEMBOURG Bender, O.; Koordinierungszentrum Klinische Studien (KKS), Charité - Universitätsmedizin Berlin, Berlin, GERMANY Boraschi, D.; Institute of Protein Biochemistry, Consiglio Nazionale delle Ricerche (CNR) di Pisa, Pisa, ITALY Borchers, F.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Dschietzig, T. B.; Immundiagnostik AG, Bensheim, GERMANY Feinkohl, I.; Molecular Epidemiology, Max-Delbrück Center (MDC), Berlin, GERMANY Fletcher, P.; Behavioural and Clinical Neurosciences Institute, Department of Medicine, University of Cambridge, Cambridge, UK Gallinat, J.; Department of Psychiatry, University of Hamburg, Hamburg, GERMANY Hadzidiakos, D.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Haynes, J. D.; Berlin Center for Advanced Neuroimaging (BCAN), Berlin, GERMANY Heppner, F.; Institute of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Hetzer, S.; Berlin Center for Advanced Neuroimaging (BCAN), Berlin, GERMANY Hendrikse, J.; Department of Radiology and Brain Center Rudolf Magnus, University Medical Center Utrecht (UMC), Utrecht, THE NETHERLANDS Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin Kant, I. M J.; Department of Intensive Care Medicine and Brain Center Rudolf Magnus, University Medical Center Utrecht (UMC), Utrecht, THE NETHERLANDS Kraft, A.; Berlin Institute of Health (BIH), Berlin, GERMANY Krannich, A.; Berlin Institute of Health (BIH), Berlin, GERMANY Krause, R.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, LUXEMBOURG Kühn, S.; Pharmaimage Biomarker Solutions GmbH, Berlin, GERMANY; Behavioural and Clinical Neurosciences Institute, Department of Medicine, University of Cambridge, Cambridge, UK; Max-Planck Inst. for Human Development, Berlin, GERMANY Lachmann, G.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY van Montfort, S. J. T.; Department of Intensive Care Medicine and Brain Center Rudolf Magnus, University Medical Center Utrecht (UMC), Utrecht, THE NETHERLANDS Müller, A.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Nürnberg, P.; Atlas Biolabs GmbH, Berlin, Germany; Cologne Center for Genomics (CCG), University of Cologne, Cologne, GERMANY Ofosu, K.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Pietsch, M.; Cellogic GmbH (Cellogic), Berlin, GERMANY Pischon, T.; Molecular Epidemiology, Max-Delbrück Center (MDC), Berlin, GERMANY Preller, J.; Department of Anesthesiology, Cambridge University Hospitals NHS Foundation Trust (CUH), Cambridge, UK Renzulli, E.; ALTA Ricerca e Sviluppo in Bioecnologie Srlu (ALTA), Siena, ITALY Scheurer, K.; Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Berlin, GERMANY; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Schneider, R.; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, LUXEMBOURG Slooter, A. J. C.; Department of Intensive Care Medicine and Brain Center Rudolf Magnus, University Medical Center Utrecht (UMC), Utrecht, THE NETHERLANDS Spies, C.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Stamatakis, E.; Behavioural and Clinical Neurosciences Institute, Department of Medicine, University of Cambridge, Cambridge, UK Volk, H. D.; Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Weber, S.; Cellogic GmbH (Cellogic), Berlin, GERMANY Wolf, A.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Yürek, F.; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, GERMANY Zacharias, N.; Experimental and Clinical Research Center (ECRC), Charté - Universitätsmedizin Berlin, Berlin, GERMANY; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; Pharmaimage Biomarker Solutions GmbH, Berlin, GERMANY
Quelle/Jahr	European Psychiatry: 50 (2018), 34 - 39
ISSN	0924-9338 (PRINT) ; 1778-3585 (ONLINE)
DOI	https://doi.org/10.1016/j.eurpsy.2017.10.004
Verlag	Amsterdam [u.a.]: Elsevier
Freie Schlagworte	Molecular biomarkers ; Multivariate prediction algorithm ; Neuroimaging ; Postoperative cognitive dysfunction ; Postoperative delirium
Zusammenfassung	Postoperative cognitive impairment is among the most common medical complications associated with surgical interventions – particularly in elderly patients. In our aging society, it is an urgent medical need to determine preoperative individual risk prediction to allow more accurate cost–benefit decisions prior to elective surgeries. So far, risk prediction is mainly based on clinical parameters. However, these parameters only give a rough estimate of the individual risk. At present, there are no molecular or neuroimaging biomarkers available to improve risk prediction and little is known about the etiology and pathophysiology of this clinical condition. In this short review, we summarize the current state of knowledge and briefly present the recently started BioCog project (Biomarker Development for Postoperative Cognitive Impairment in the Elderly), which is funded by the European Union. It is the goal of this research and development (R&D) project, which involves academic and industry partners throughout Europe, to deliver a multivariate algorithm based on clinical assessments as well as molecular and neuroimaging biomarkers to overcome the currently unsatisfying situation.

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Winterer, G., Androsova, G., Bender, O., Boraschi, D., Borchers, F., Dschietzig, T. B., Feinkohl, I., Fletcher, P., Gallinat, J., Hadzidiakos, D., Haynes, J. D., Heppner, F., Hetzer, S., Hendrikse, J., Ittermann, B., Kant, I. M. J., Kraft, A., Krannich, A., Krause, R., Kühn, S., Lachmann, G., van Montfort, S. J. T., Müller, A., Nürnberg, P., Ofosu, K., Pietsch, M., Pischon, T., Preller, J., Renzulli, E., Scheurer, K., Schneider, R., Slooter, A. J. C., Spies, C., Stamatakis, E., Volk, H. D., Weber, S., Wolf, A., Yürek, F., & Zacharias, N. (2018). Personalized risk prediction of postoperative cognitive impairment - rationale for the EU-funded BioCog project. European Psychiatry, 50, 34–39. https://doi.org/10.1016/j.eurpsy.2017.10.004

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