| Zugriffsnummer | 39875 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Infrared nanospectroscopy of phospholipid and surfactin monolayer domains |
| Autor(in); Institution |
Kästner, Bernd; 7.2, Kryophysik und Spektrometrie, PTB-Berlin
Johnson, M.; KTH Royal Institute of Technology, Stockholm, SWEDEN
Hermann, Peter; 7.2, Kryophysik und Spektrometrie, PTB-Berlin
Kruskopf, Mattias; 2.5, Halbleiterphysik und Magnetismus, PTB-Braunschweig
Pierz, Klaus; 2.5, Halbleiterphysik und Magnetismus, PTB-Braunschweig
Hoehl, Arne; 7.2, Kryophysik und Spektrometrie, PTB-Berlin
Hornemann, Andrea; 7.2, Kryophysik und Spektrometrie, PTB-Berlin
Ulrich, Georg; 7.2, Kryophysik und Spektrometrie, PTB-Berlin
Fehmel, Jakob; 7.2, Kryophysik und Spektrometrie, PTB-Berlin
Patoka, Piotr; Freie Uni Berlin, GERMANY
Rühl, E.; Freie Uni Berlin, GERMANY
Ulm, Gerhard; 7, Temperatur und Synchrotronstrahlung, PTB-Berlin
|
| Quelle/Jahr | ACS Omega: 3 (2018), 4141 - 4147 |
| Availability | [online only] |
| ISSN | 2470-1343 |
| DOI | |
| Verlag | Washington, DC: ACS Publications |
| Freie Schlagworte | Scanning near-field optical microscopy (SNOM), ; synchrotron-based nano-FTIR spectroscopy ; phospholipid monolayers, ; surfactin, graphene |
| Zusammenfassung | A main challenge in understanding the structure of a cell membrane and its interactions with drugs is the ability to chemically study the different molecular species on the nanoscale. We haveachieved this for a model system consisting of mixed monolayers of the biologically relevant phospholipid DSPC and the antibiotic surfactin. By employing nano infrared (IR) microscopy and spectroscopy in combination with AFM imaging it was possible to identify and chemically detect domain formation of the two constituents, as well as to obtain IR spectra of these species with a spatial resolution on the nanoscale. A novel method to enhance the near-field imaging contrast of organic monolayers by plasmon interferometry is proposed and demonstrated. In this technique, the organic layer is deposited on gold and monolayer graphene substrates, the latter of which supports propagating surface plasmons. Plasmon reflections arising from changes in the dielectric environment provided by the organic layer lead to an additional contrast mechanism. Using this approach the interfacial region between surfactin and the phospholipid has been mapped and a transition region is identified. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 3.0 ; Creative Commons Attribution 3.0 License ; ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes |
Zitierung
Kästner, B., Johnson, M., Hermann, P., Kruskopf, M., Pierz, K., Hoehl, A., Hornemann, A., Ulrich, G., Fehmel, J., Patoka, P., Rühl, E., & Ulm, G. (2018). Infrared nanospectroscopy of phospholipid and surfactin monolayer domains. ACS Omega, 3, 4141–4147. https://doi.org/10.1021/acsomega.7b01931