| Zugriffsnummer | 39646 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Psychosocial stress and brain function in adolescent psychopathology |
| Autor(in); Institution |
Burke Quinlan, E.; not affiliated
Cattrell, A.; not affiliated
Jia, T.; not affiliated
Artiges, E.; not affiliated
Banaschewski, T.; not affiliated
Barker, G.; not affiliated
Bokde, A. L. W.; not affiliated
Bromberg, U.; not affiliated
Büchel, C.; not affiliated
Brühl, Rüdiger; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Conrod, P. J.; not affiliated
Desrivieres, S.; not affiliated
Flor, H.; not affiliated
Frouin, V.; not affiliated
Gallinat, J.; not affiliated
Garavan, H.; not affiliated
Gowland, P.; not affiliated
Heinz, A.; not affiliated
Martinot, J.-L.; not affiliated
Paillére Martinot, M.-L.; not affiliated
Nees, F.; not affiliated
Papadopoulos-Orfanos, D.; not affiliated
Paus, T.; not affiliated
Poustka, L.; not affiliated
Smolka, M. N.; not affiliated
Vetter, N. C.; not affiliated
Walter, H.; not affiliated
Whelan, R.; not affiliated
Glennon, J. C.; not affiliated
Buitelaar, J. K.; not affiliated
Happé, F.; not affiliated
Loth, E.; not affiliated
Barker, E. D.; not affiliated
Schumann, G.; not affiliated
|
| Quelle/Jahr | American Journal of Psychiatry: 174 (2017), 8, 785 - 794 |
| ISSN | 0002-953X (PRINT) ; 1535-7228 (ONLINE) |
| DOI | |
| Verlag | Arlington, Va.: American Psychiatric Publishing (APA) |
| Freie Schlagworte | Attention Deficit Hyperactivity Disorder ; Conduct Disorder ; Emotion ; Magnetic Resonance Imaging ; Adolescents ; Stress |
| Zusammenfassung | Objective: The authors sought to explore how conduct, hyperactivity/inattention, and emotional symptoms are associated with neural reactivity to social-emotional stimuli, and the extent to which psychosocial stress modulates these relationships. Method: Participants were community adolescents recruited as part of the European IMAGEN study. Bilateral amygdala regions of interest were used to assess the relationship between the three symptom domains and functional MRI neural reactivity during passive viewing of dynamic angry and neutral facial expressions. Exploratory functional connectivity and whole brain multiple regression approaches were used to analyze how the symptoms and psychosocial stress relate to other brain regions. Results: In response to the social-emotional stimuli, adolescents with high levels of conduct or hyperactivity/inattention symptoms who had also experienced a greater number of stressful life events showed hyperactivity of the amygdala and several regions across the brain. This effect was not observed with emotional symptoms. A cluster in the midcingulate was found to be common to both conduct problems and hyperactivity symptoms. Exploratory functional connectivity analyses suggested that amygdalaprecuneus connectivity is associated with hyperactivity/inattention symptoms. Conclusions: The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights the importance of studying how psychosocial stress affects functional brain responses to social-emotional stimuli, particularly in adolescents with externalizing symptoms. |
Zitierung
Burke Quinlan, E., Cattrell, A., Jia, T., Artiges, E., Banaschewski, T., Barker, G., Bokde, A. L. W., Bromberg, U., Büchel, C., Brühl, R., Conrod, P. J., Desrivieres, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Martinot, J.-L., Paillére Martinot, M.-L., Nees, F., Papadopoulos-Orfanos, D., Paus, T., Poustka, L., Smolka, M. N., Vetter, N. C., Walter, H., Whelan, R., Glennon, J. C., Buitelaar, J. K., Happé, F., Loth, E., Barker, E. D., & Schumann, G. (2017). Psychosocial stress and brain function in adolescent psychopathology. American Journal of Psychiatry, 174(8), 785–794. https://doi.org/10.1176/appi.ajp.2017.16040464