| Zugriffsnummer | 39559 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Magnetic nanoparticles interact with and pass an in vitro blood-placenta barrier model |
| Autor(in); Institution |
Müller, E.K.; Klinik für Innere Medizin II, Abt. Hämatologie & Internistische Onkologie, Universitätsklinikum Jena, Jena, GERMANY
Gräfe, C.; Klinik für Innere Medizin II, Abt. Hämatologie & Internistische Onkologie, Universitätsklinikum Jena, Jena, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
Dutz, S.; Institut für Biomedizinische Technik und Informatik, Technische Universität Ilmenau, Ilmenau, GERMANY
Hochhaus, A.; Klinik für Innere Medizin II, Abt. Hämatologie & Internistische Onkologie, Universitätsklinikum Jena, Jena, GERMANY
Clement, J.H.; Klinik für Innere Medizin II, Abt. Hämatologie & Internistische Onkologie, Universitätsklinikum Jena, Jena, GERMANY
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| Quelle/Jahr | 16th German Ferrofluid Workshop: Dresden July 17th – 19th 2017:(2017), 110 - 111 |
| Konferenzangaben | 16th Ferrofluid Workshop 2017, Dresden, 17-19, July, 2017, GERMANY |
| Zusammenfassung | Research activities concerning the application of nanomaterials in medicine have rapidly increased in the last years. Especially superparamagnetic iron oxide nanoparticles (SPIONs) are of great interest for example as drug delivery agents or contrast agents in MRI scans due to their unique physiochemical properties and functionalization. A prerequisite for any application of SPIONs is the knowledge about the Impact of these nanoparticles onto the human body, whereby the interaction with biological tissues and cells plays a decisive role. In pregnant women, the blood-placenta barrier (BPB) segregates the maternal and the foetal blood supply and is important for the bidirectional transfer of important substances such as oxygen, nutrients and hormones. On one hand SPIONs applied to pregnant women might penetrate the BPB or disrupt its barrier integrity as off-target effect. On the other hand, nanomaterials like SPIONs, might offer the opportunity to selectively target the pregnant woman, the foetus or the placenta for the treatment of various complications and diseases during pregnancy. For all of these situations, the behavior of the particles in the BPB concerning interaction and passage through the interface and possible teratogenic effects should be investigated in more detail. In this study, an in vitro model of the BPB was established and optimized to study the interaction and passage of three differently charged SPIONs through this interface. |
