| Zugriffsnummer | 39558 |
| Dokumenttyp | Konferenzartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Interaction of iron oxide nanoparticles with breast cancer cells |
| Autor(in); Institution |
Friedrich, R.; Universitätsklinikum Erlangen, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftung-Professorship, Erlangen, GERMANY
Poller, J.; Universitätsklinikum Erlangen, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftung-Professorship, Erlangen, GERMANY
Zaloga, J.; Universitätsklinikum Erlangen, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftung-Professorship, Erlangen, GERMANY
Schreiber, E.; Universitätsklinikum Erlangen, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftung-Professorship, Erlangen, GERMANY
Unterweger, H.; Universitätsklinikum Erlangen, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftung-Professorship, Erlangen, GERMANY
Janko, C.; Universitätsklinikum Erlangen, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftung-Professorship, Erlangen, GERMANY
Radon, Patricia; 8.2, Biosignale, PTB-Berlin
Eberbeck, Dietmar; 8.2, Biosignale, PTB-Berlin
Trahms, Lutz; 8.2, Biosignale, PTB-Berlin
Alexiou, C.; Universitätsklinikum Erlangen, Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius Stiftung-Professorship, Erlangen, GERMANY
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| Quelle/Jahr | 16th German Ferrofluid Workshop: Dresden July 17th – 19th 2017:(2017), 98 - 99 |
| Konferenzangaben | 16th Ferrofluid Workshop 2017, Dresden, 17-19, July, 2017, GERMANY |
| Zusammenfassung | Superparamagnetic iron oxide nanoparticles (SPIONs) have gained increasing importance as promising new tools for biomedical applications. In this investigation, we studied the influence of physicochemical properties like particle size, Zeta potential and coating of various SPIONs on particle uptake, cell proliferation and viability of various human breast cancer cell lines. To address the heterogeneity of nanoparticles and cells, we synthesized 3 different, precisely characterized SPIONs (lauric acid-coated SPIONs [SPIONLA], lauric acid and human serum albumin-coated SPIONs [SPIONLA-HSA] and dextran-coated SPIONs [SPIONDex]). We investigated their effects on 4 breast cancer cell lines (T-47D, BT-474, MCF7 and MDA-MB- 231) belonging to different subtypes, as defined by receptor expression and proliferation rates. As a tumor-unrelated control, we used human umbilical vein endothelial cells (HUVECs). We analyzed cellular SPION uptake, magnetic properties, cell proliferation and toxicity using atomic emission spectroscopy, magnetic susceptometry,flow cytometry and microscopy. |
Zitierung
Friedrich, R., Poller, J., Zaloga, J., Schreiber, E., Unterweger, H., Janko, C., Radon, P., Eberbeck, D., Trahms, L., & Alexiou, C. (2017). Interaction of iron oxide nanoparticles with breast cancer cells. 16th Ferrofluid Workshop 2017, Dresden, 17-19, July, 2017, GERMANY.