| Zugriffsnummer | 39555 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | The passage of SPIONs through an in vitro blood-brain barrier is dependent on the SPIONs’ surface charge |
| Autor(in); Institution |
Gräfe, C.; Klinik für Innere Medizin II, Abt. Hämatologie & Internistische Onkologie, Universitätsklinikum Jena, Jena, GERMANY
Slabu, Ioana; 8.2, Biosignale, PTB-Berlin
Weidner, A.; Institut für Biomedizinische Technik und Informatik, Technische Universität Ilmenau, Ilmenau, GERMANY
Schreiber, E.; Sektion für Experimentelle Onkologie und Nanomedizin, Universitätsklinikum Erlangen, Erlangen, GERMANY
Friedrich, R.P.; Sektion für Experimentelle Onkologie und Nanomedizin, Universitätsklinikum Erlangen, Erlangen, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
Alexiou, C.; Sektion für Experimentelle Onkologie und Nanomedizin, Universitätsklinikum Erlangen, Erlangen, GERMANY
Dutz, S.; Institut für Biomedizinische Technik und Informatik, Technische Universität Ilmenau, Ilmenau, GERMANY
Hochhaus, A.; Klinik für Innere Medizin II, Abt. Hämatologie & Internistische Onkologie, Universitätsklinikum Jena, Jena, GERMANY
Clement, J.H.; Klinik für Innere Medizin II, Abt. Hämatologie & Internistische Onkologie, Universitätsklinikum Jena, Jena, GERMANY
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| Quelle/Jahr | 16th German Ferrofluid Workshop: Dresden July 17th – 19th 2017:(2017), 102 - 103 |
| Konferenzangaben | 16th Ferrofluid Workshop 2017, Dresden, 17-19, July, 2017, GERMANY |
| Zusammenfassung | Biological barriers such as the blood-brain barrier constitute highly specialized and selective semipermeable membrane tissues. On the one hand its integrity should not accidentally be affected. On the other hand they act as obstacle for numerous drugs making sufficient and targeted drug delivery a mayor challenge. Thus, dedicated strategies and drug delivery systems specially designed for the definite application are developed. Based on their huge diversity and functionalization capacity uperparamagnetic iron oxide nanoparticles (SPIONs) are highly attractive candidates for accomplishing not only drug delivery but also utilizing them as contrast-enhancing agents in magnet-based imaging techniques and in hyperthermia cancer therapy. However, for a successful implementation, a detailed knowledge concerning their interaction with cellular interfaces and their effect on barrier integrity are of essential importance. In order to study these aspects we establish a standardized in vitro test system to investigate and understand the passage of coated SPIONs through cell layers driven by magnetic forces. |
Zitierung
Gräfe, C., Slabu, I., Weidner, A., Schreiber, E., Friedrich, R., Wiekhorst, F., Alexiou, C., Dutz, S., Hochhaus, A., & Clement, J. (2017). The passage of SPIONs through an in vitro blood-brain barrier is dependent on the SPIONs’ surface charge. 16th Ferrofluid Workshop 2017, Dresden, 17-19, July, 2017, GERMANY.