| Zugriffsnummer | 39265 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Impact of a common genetic variation associated with putamen volume on neural mechanisms of attention-deficit/hyperactivity disorder |
| Autor(in); Institution |
Xu, Bing; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UNITED KINGDOM
Jia, Tianye; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UNITED KINGDOM
Macare, Christine; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UNITED KINGDOM
Banaschewski, Tobias; Clinical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, GERMANY
Bokde, Arun L.W.; Discipline of Psychiatry, School of Medicine and the Trinity College Institute of Neurosciences, Trinity College Dublin, IRELAND
Bromberg, Uli; University Medical Centre Hamburg-Eppendorf, GERMANY
Büchel, Christian; University Medical Centre Hamburg-Eppendorf, GERMANY
Cattrell, Ann; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UNITED KINGDOM
Conrod, Patricia J.; Université de Montreal, Centre Hospitalier Universitaire Sainte-Justine, Montreal, CANADA
Flor, Herta; Central Institute of Mental Health, Medical Faculty Mannheim, GERMANY
Frouin, Vincent; Neurospin, Commissariat à l’Energie Atomique, CEA-Saclay Center, Paris, FRANCE
Gallinat, Jürgen; University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Garavan, Hugh; University of Vermont, Burlington, USA
Gowland, Penny; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, UNITED KINGDOM
Heinz, Andreas; Campus Charité Mitte, Charité, Universitätsmedizin Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, Jean-Luc; University Paris Descartes, Sorbonne Paris Cité and Maison de Solenn, Paris, FRANCE
Paillère Martinot, Marie-Laure; University Paris Descartes, Sorbonne Paris Cité and Maison de Solenn, Paris, FRANCE
Ness, Frauke; Central Institute of Mental Health, Medical Faculty Mannheim, GERMANY
Papadopoulos-Orfanos, Dimitri; Neurospin, Commissariat à l’Energie Atomique, CEA-Saclay Center, Paris, FRANCE
Paus, Tomáš; Rotman Research Institute, Baycrest and the University of Toronto, CANADA
Poustka, Luise; Clinical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, GERMANY
Smolka, Michael N.; Technische Universität Dresden, GERMANY
Walter, Henrik; Campus Charité Mitte, Charité, Universitätsmedizin Berlin, GERMANY
Whelan, Robert; University College Dublin, IRELAND
Schumann, Gunter; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UNITED KINGDOM
Desrivières, Sylvane; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UNITED KINGDOM
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| Quelle/Jahr | Journal of the American Academy of Child and Adolescent Psychiatry: 56 (2017), 5, 436 - 444 |
| ISSN | 1527-5418 (PRINT) ; 0890-8567 (ONLINE) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Konferenzangaben | 22nd Annual Meeting of the Organization for Human Brain Mapping, Geneve, June 26–30, 2016, Switzerland |
| Freie Schlagworte | rs945270 ; putamen ; attention-deficit/hyperactivity disorder ; reward anticipation ; response control |
| Zusammenfassung | Objective In a recent genomewide association study of subcortical brain volumes, a common genetic variation at rs945270 was identified as having the strongest effect on putamen volume, a brain measurement linked to familial risk for attention-deficit/hyperactivity disorder (ADHD). To determine whether rs945270 might be a genetic determinant of ADHD, its effects on ADHD-related symptoms and neural mechanisms of ADHD, such as response inhibition and reward sensitivity, were explored. Method A large population sample of 1,834 14-year-old adolescents was used to test the effects of rs945270 on ADHD symptoms assessed through the Strengths and Difficulties Questionnaire and region-of-interest analyses of putamen activation by functional magnetic resonance imaging using the stop signal and monetary incentive delay tasks, assessing response inhibition and reward sensitivity, respectively. Results There was a significant link between rs945270 and ADHD symptom scores, with the C allele associated with lower symptom scores, most notably hyperactivity. In addition, there were sex-specific effects of this variant on the brain. In boys, the C allele was associated with lower putamen activity during successful response inhibition, a brain response that was not associated with ADHD symptoms. In girls, putamen activation during reward anticipation increased with the number of C alleles, most significantly in the right putamen. Remarkably, right putamen activation during reward anticipation tended to negatively correlate with ADHD symptoms. Conclusion These results indicate that rs945270 might contribute to the genetic risk of ADHD partly through its effects on hyperactivity and reward processing in girls. |
Zitierung
Xu, B., Jia, T., Macare, C., Banaschewski, T., Bokde, A. L., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère Martinot, M.-L., Ness, F., Papadopoulos-Orfanos, D., Paus, T., Poustka, L., Smolka, M. N., Walter, H., Whelan, R., Schumann, G., & Desrivières, S. (2017). Impact of a common genetic variation associated with putamen volume on neural mechanisms of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 56(5), 436–444. https://doi.org/10.1016/j.jaac.2017.02.009