| Zugriffsnummer | 39160 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Nanodosimetry: Towards a new concept of radiation quality |
| Autor(in); Institution |
Conte, V.; Legnaro National Laboratories (INFN), Legnaro, ITALY
Selva, A.; Legnaro National Laboratories (INFN), Legnaro, ITALY; University of Padova, Department of Physics and Astronomy, Padova, ITALY
Colautti, P.; Legnaro National Laboratories (INFN), Legnaro, ITALY
Hilgers, Gerhard; 6.5, Strahlenwirkung, PTB-Braunschweig
Rabus, Hans; 6.5, Strahlenwirkung, PTB-Braunschweig
Bantsar, A.; National Centre for Nuclear Research (NCBJ), Otwock-Swierk, POLAND
Pietrzak, M.; National Centre for Nuclear Research (NCBJ), Otwock-Swierk, POLAND; University of Warsaw, Faculty of Physics, Warsaw, POLAND
Pszona, S.; National Centre for Nuclear Research (NCBJ), Otwock-Swierk, POLAND
|
| Quelle/Jahr | Radiation Protection Dosimetry: 180 (2018), 1-4, 150 - 156 |
| ISSN | 0144-8420 (PRINT) ; 1742-3406 (ONLINE) |
| DOI | |
| Verlag | Oxford: Oxford University Press |
| Konferenzangaben | Neutron and Ion Dosimetry Symposium, NEUDOS-13, Krakau, 14-19, May, 2017, Poland |
| Freie Schlagworte | Nanodosimetry ; radiobiology ; BioQuaRT ; MITRA ; radiation quality |
| Zusammenfassung | The biological action of ionizing charged particles is initiated at the DNA level, and the effectiveness with which the initial physical effect changes into measurable biological damage is likely ruled by the stochastics of ionizations produced by the incident ions in subcellular nanometric volumes. Based on this hypothesis, experimental nanodosimetry aims at establishing a new concept of radiation quality that builds on measurable characteristics of the particle track structure at the nanometre scale. Three different nanodosimetric detection systems have been developed to date that allow measurements of the number of ionizations produced by the passage of a primary particle in a nanometer-size gas volume (in unit density scale). Within the Italian project MITRA (MIcrodosimetry and TRAck structure), funded by the Italian Istituto Nazionale di Fisica Nucleare (INFN), and the EMRP Joint Research Project "BioQuaRT" (Biologically Weighted Quantities in Radiotherapy), experiments have been carried out, in which the frequency distribution of ionizations produced by proton and carbon ion beams of given energy was measured with the three nanodosimetric detectors. Descriptors of the track structure can be derived from these distributions. In particular, the first moment M1, representing the mean number of ionizations produced in the target volume, and the cumulative probability Fk of measuring a number ν ≥ k of ionizations. The correlation between measured nanodosimetric quantities and experimental radiobiological data available in the literature is here presented and discussed. |
