| Zugriffsnummer | 39094 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition |
| Autor(in); Institution |
Deng, W.; Shanghai Center for Mathematical Sciences, Fudan Univ., Shanghai, CHINA
Rolls, E.; Department of Computer Sciences, Univ. of Warwick, Coventry, UK
Ji, X.; Center for Computional Systems Biology, Fudan Univ., Shanghai, CHINA
Robbins, T.; Department of Psychology, Univ. of Cambridge, UK
Banaschewski, Tobias; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, Trinity College Dublin, IRELAND
Bromberg, U.; University Medical Centre Hamburg Eppendorf, Hamburg, GERMANY
Büchel, Christian; Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Desrivières, S.; Medical Research Council-Social, Genetic and Development Psychiatry Centre, Kings College, London, UK
Conrod, P.; Department of Psychiatry, Universite de Montreal, Montreal, CANADA
Flor, H.; Department of Cognitive and Clinical Neuroscience, Heidelberg University, Mannheim, GERMANY
Frouin, V.; Neurospin, DEA-Saclay Center, Paris, FRANCE
Gallinat, Jürgen; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin, Berlin, GERMANY
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, USA
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, Univ. of Nottingham, UK
Heinz, Andreas; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Sante et de la Recherche Medicale, INSERM Unit 1000, Paris, FRANCE
Lemaitre, H.; Institut National de la Sante et de la Recherche Medicale, INSERM Unit 1000, Paris, FRANCE
Nees, F.; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim, GERMANY
Papadopoulos Orfanos, D.; Neurospin, DEA-Saclay Center, Paris, FRANCE
Poustka, L.; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Mannheim, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin, Berlin, GERMANY
Whelan, R.; Department of Psychology, University College Dublin, IRELAND
Schumann, G.; Medical Research Council-Social, Genetic and Development Psychiatry Centre, Kings College, London, UK
Feng, J.; Shanghai Center for Mathematical Sciences, Fudan Univ., Shanghai, CHINA
|
| Quelle/Jahr | Human Brain Mapping: 38 (2017), 7, 3527 - 3537 |
| ISSN | 1065-9471 (PRINT) ; 1097-0193 (ONLINE) |
| DOI | |
| Verlag | New York, NY: Wiley-Liss |
| Freie Schlagworte | cingulate cortex ; depression ; impulsive behavior ; inhibition ; insula ; orbitofrontal cortex |
| Zusammenfassung | To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop-signal task, in 1709 participants. First, areas activated more in stop-success (SS) than stop-failure (SF) included the lateral orbitofrontal cortex (OFC) extending into the inferior frontal gyrus (ventrolateral prefrontal cortex, BA 47/12), and the dorsolateral prefrontal cortex (DLPFC). Second, the anterior cingulate and anterior insula (AI) were activated more on failure trials, specifically in SF versus SS. The interaction between brain region and SS versus SF activations was significant (P=5.6*10-8). The results provide new evidence from this "big data" investigation consistent with the hypotheses that the lateral OFC is involved in the stop-related processing that inhibits the action; that the DLPFC is involved in attentional processes that influence task performance; and that the AI and anterior cingulate are involved in emotional processes when failure occurs. The investigation thus emphasizes the role of the human lateral OFC BA 47/12 in changing behavior, and inhibiting behavior when necessary. A very similar area in BA47/12 is involved in changing behavior when an expected reward is not obtained, and has been shown to have high functional connectivity in depression. |
Zitierung
Deng, W., Rolls, E., Ji, X., Robbins, T., Banaschewski, T., Bokde, A., Bromberg, U., Büchel, C., Desrivières, S., Conrod, P., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Lemaitre, H., Nees, F., Papadopoulos Orfanos, D., Poustka, L., Smolka, M., Walter, H., Whelan, R., Schumann, G., & Feng, J. (2017). Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition. Human Brain Mapping, 38(7), 3527–3537. https://doi.org/10.1002/hbm.23607