| Zugriffsnummer | 38043 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Functional neuroimaging predictors of self-reported psychotic symptoms in adolescents |
| Autor(in); Institution |
Bourque, J.; not affiliated
Spechler, P. A.; Department of Psychiatry, University of Vermont, USA; College of Medicine, Burlington, Vermont, USA
Potvin, S.; not affiliated
Whelan, R.; Department of Psychology, University College Dublin, Dublin, IRELAND
Banaschewski, T.; Central Institute of Mental Health, Mannheim, GERMANY; Medical Faculty Mannheim, University of Heidelberg, GERMANY
Bokde, A. L.; Institue of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; Universitaetsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Quinlan, E. B.; not affiliated
Desrivières, S.; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, University of Nottingham, Nottingham, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Frouin, V.; Neurospin, Commissariat à l’Energie Atomique, CEA Saclay Center, Paris, FRANCE
Gowland, P.; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Martinot, J.-L.; Institut National de la Santé et de la Recherche Médicale Unit 1000 Neuroimaging and Psychiatry, University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn, Paris, FRANCE
Paillère-Martinot, M.-L.; Department of Psychiatry and Psychotherapy, Charité University Medicine Campus Mitte, Berlin, GERMANY
McEwen, S. C.; not affiliated
Nees, F.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Orfanos, D. P.; Neurospin, Commissariat à l’Energie Atomique, CEA Saclay Center, Paris, FRANCE
Paus, T.; Rotman Research Institute, Baycrest, and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Poustka, L.; Department of Child and Adolescnet Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Smolka, M. N.; Neuroimaging Center, Department of Psychiatry and Psychotherapy, Technische Universiät Dresden, GERMANY
Vetter, N. C.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Schumann, G.; Institute of Psychiatry, King's College London, London, UK
Conrod, P. J.; Department of Psychiatry, Universite de Montreal, CHU Ste Jutine Hospital, Montreal, Quebec, CANADA
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| Quelle/Jahr | American Journal of Psychiatry: 174 (2017), 6, 566 - 575 |
| ISSN | 0002-953X (PRINT) ; 1535-7228 (ONLINE) |
| DOI | |
| Verlag | Arlington, Va.: American Psychiatric Assoc. |
| Freie Schlagworte | Adolescents ; Psychosis ; Mood Disorders-Bipolar ; Brain Imaging Techniques |
| Zusammenfassung | Objective: This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing. A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later. Method: Functional imaging responses to three paradigms - the stop-signal, monetary incentive delay, and faces tasks - were collected in youths at age 14, as part of the IMAGEN study. At baseline, youths from London and Dublin sites were assessed on psychotic-like experiences, and those reporting significant experiences were compared with matched control subjects. Significant brain activity differences between the groups were used to predict, with cross-validation, the presence of psychotic symptoms in the context of mood fluctuation at age 16, assessed in the full sample. These prediction analyses were conducted with the London-Dublin subsample (N=246) and the full sample (N=1,196). Results: Relative to control subjects, youths reporting psychotic-like experiences showed increased hippocampus/amygdala activity during processing of neutral faces and reduced dorsolateral prefrontal activity during failed inhibition. The most prominent regional difference for classifying 16-year-olds with mood fluctuation and psychotic symptoms relative to the control groups (those with mood fluctuations but no psychotic symptoms and those with no mood symptoms) was hyperactivation of the hippocampus/amygdala, when controlling for baseline psychotic-like experiences and cannabis use. Conclusions: The results stress the importance of the limbic network’s increased response to neutral facial stimuli as a marker of the extended psychosis phenotype. These findings might help to guide early intervention strategies for at-risk youths. |
Zitierung
Bourque, J., Spechler, P. A., Potvin, S., Whelan, R., Banaschewski, T., Bokde, A. L., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., Flor, H., Frouin, V., Gowland, P., Heinz, A., Ittermann, B., Martinot, J.-L., Paillère-Martinot, M.-L., McEwen, S. C., Nees, F., Orfanos, D. P., Paus, T., Poustka, L., Smolka, M. N., Vetter, N. C., Walter, H., Schumann, G., & Conrod, P. J. (2017). Functional neuroimaging predictors of self-reported psychotic symptoms in adolescents. American Journal of Psychiatry, 174(6), 566–575. https://doi.org/10.1176/appi.ajp.2017.16080897