| Zugriffsnummer | 37892 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents |
| Autor(in); Institution |
Büchel, C.; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Peters, J.; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Banaschewski, T.; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Bokde, A.; Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Conrod, P.; Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montréal, Québec, CANADA
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Papadopoulos, D.; Commissariat à l’Energie Atomique et aux Energies Alternatives, 14 CEA, DSV, I2BM, Gif-sur-Yvette, FRANCE
Garavan, H.; Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Gowland, P.; School of Physics and Astronomy, University of Nottingham, Nottinghamshire, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
Mann, K.; Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Martinot, J.-L.; Institut National de la Sante' et de la Recherche Medicale, INSERM Unit 1000 Imaging & Psychiatry, University Paris-Sud, Orsay, FRANCE
Paillere-Martinot, M.-L.; Institut National de la Sante' et de la Recherche Medicale, INSERM Unit 1000 Imaging & Psychiatry, University Paris-Sud, Orsay, FRANCE
Nees, F.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Paus, T.; McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, CANADA
Pausova, Z.; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Rietschel, M.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Robbins, T.; Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Smolka, M.; Department of Psychiatry and Psychotherapy, and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Gallinat, J.; Department of Psychiatry and Psychotherapy, Campus Charite' Mitte, Charite' - Universitätsmedizin Berlin, Berlin, GERMANY
Schumann, G.; Institute of Psychiatry, King’s College London, London, UK
Knutson, B.; Department of Psychology, Stanford University, Stanford, California, USA
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| Quelle/Jahr | Nature Communications: 8 (2017), 1 - 11 |
| Artikelnummer | 14140 |
| Availability | [online only] |
| ISSN | 2041-1723 |
| DOI | |
| Verlag | London: Nature Publishing Group |
| Zusammenfassung | Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hyporesponsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Büchel, C., Peters, J., Banaschewski, T., Bokde, A., Bromberg, U., Conrod, P., Flor, H., Papadopoulos, D., Garavan, H., Gowland, P., Heinz, A., Walter, H., Ittermann, B., Mann, K., Martinot, J.-L., Paillere-Martinot, M.-L., Nees, F., Paus, T., Pausova, Z., Poustka, L., Rietschel, M., Robbins, T., Smolka, M., Gallinat, J., Schumann, G., & Knutson, B. (2017). Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. Nature Communications, 8, 1–11. https://doi.org/10.1038/ncomms14140