| Zugriffsnummer | 37677 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Early cannabis use, polygenic risk score for schizophrenia and brain maturation in adolescence |
| Autor(in); Institution |
French, L.; Rotman Research Institute, Baycrest, Toronto, Ontario, CANADA
Gray, C.; Rotman Research Institute, Baycrest, Toronto, Ontario, CANADA
Leonard, G.; Montreal Neurological Institute, McGill University, Montreal, Quebec, CANADA
Perron, M.; Groupe d'Étude des Conditions de vie et des Besoins de la Population, Cégep de Jonquiere, Jonquiere, Saguenay, Quebec, Canada Department of Human Sciences, University of Quebec in Chicoutimi, Chicoutimi, Quebec, CANADA
Pike, G.; Department of Radiology, University of Calgary, Calgary, Alberta, Canada6Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, CANADA
Richter, L.; Department of Health Sciences, University of Quebec in Chicoutimi, Chicoutimi, Quebec, CANADA
Séguin, J.; Department of Psychiatry and Centre de Recherche du Centre Hospitalier Universitaire Ste-Justine, University de Montréal, Montreal, Quebec, CANADA
Veillette, S.; Groupe d'Étude des Conditions de vie et des Besoins de la Population, Cégep de Jonquiere, Jonquiere, Saguenay, Quebec, Canada 4Department of Human Sciences, University of Quebec in Chicoutimi, Chicoutimi, Quebec, CANADA
Evans, C.; School of Psychology, Cardiff University, Cardiff, Wales, UK
Artiges, E.; Institut National de la Santé et de la Recherche Medicale (INSERM), Unité Mixte de Recherche (UMR) 1000, Research Unit Imaging and Psychiatry, Commissariat à l'Énergie Atomique (CEA), Direction des Sciences du Vivant, Institut d'Imagerie Biomédicale
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, Al.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Brühl, Rüdiger; 8.1, Medizinische Messtechnik, PTB-Berlin
Buchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Cattrell, A.; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College, London, UK
Conrod, PJ.; Department of Psychiatry, Universite de Montreal, CHU Ste Jutine Hospital, Montreal, Quebec, CANADA
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Frouin, V.; Neurospin, Commissariat à l'Energie Atomique, Paris, FRANCE
Gallinat, J.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, P.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Heinz, A.; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin, Berlin, GERMANY
Martinot, JP.; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1000, Neuroimaging and Psychiatry Research Unit, University Paris-Sud, Orsay, FRANCE
Nees, F.; Rotman Research Institute, Baycrest Health Sciences, and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Orfanos, D.P.; Department of Child and Adolescent Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AUSTRIA
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| Quelle/Jahr | JAMA Psychiatry: 72 (2015), 10, 1002 - 1011 |
| ISSN | 2168-622X (PRINT) ; 2168-6238 (ONLINE) |
| DOI | |
| Verlag | Chicago, Ill.: American Medical Association (AMA) |
| Zusammenfassung | IMPORTANCE: Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. OBJECTIVE: To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a polygenic risk score for schizophrenia. DESIGN, SETTING, AND PARTICIPANTS: Observation of 3 population-based samples included initial analysis in 1024 adolescents of both sexes from the Canadian Saguenay Youth Study (SYS) and follow-up in 426 adolescents of both sexes from the IMAGEN Study from 8 European cities and 504 male youth from the Avon Longitudinal Study of Parents and Children (ALSPAC) based in England. A total of 1577 participants (aged 12-21 years; 899 [57.0%] male) had (1) information about cannabis use; (2) imaging studies of the brain; and (3) a polygenic risk score for schizophrenia across 108 genetic loci identified by the Psychiatric Genomics Consortium. Data analysis was performed from March 1 through December 31, 2014. MAIN OUTCOMES AND MEASURES: Cortical thickness derived from T1-weighted magnetic resonance images. Linear regression tests were used to assess the relationships between cannabis use, cortical thickness, and risk score. RESULTS: Across the 3 samples of 1574 participants, a negative association was observed between cannabis use in early adolescence and cortical thickness in male participants with a high polygenic risk score. This observation was not the case for low-risk male participants or for the low- or high-risk female participants. Thus, in SYS male participants, cannabis use interacted with risk score vis-à-vis cortical thickness (P = .009); higher scores were associated with lower thickness only in males who used cannabis. Similarly, in the IMAGEN male participants, cannabis use interacted with increased risk score vis-à-vis a change in decreasing cortical thickness from 14.5 to 18.5 years of age (t137 = -2.36; P = .02). Finally, in the ALSPAC high-risk group of male participants, those who used cannabis most frequently (≥61 occasions) had lower cortical thickness than those who never used cannabis (difference in cortical thickness, 0.07 [95% CI, 0.01-0.12]; P = .02) and those with light use ((5 occasions) (difference in cortical thickness, 0.11 [95% CI, 0.03-0.18]; P = .004). CONCLUSIONS AND RELEVANCE: Cannabis use in early adolescence moderates the association between the genetic risk for schizophrenia and cortical maturation among male individuals. This finding implicates processes underlying cortical maturation in mediating the link between cannabis use and liability to schizophrenia. |
Zitierung
French, L., Gray, C., Leonard, G., Perron, M., Pike, G., Richter, L., Séguin, J., Veillette, S., Evans, C., Artiges, E., Banaschewski, T., Bokde, A., Bromberg, U., Brühl, R., Buchel, C., Cattrell, A., Conrod, P., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Martinot, J., Nees, F., & Orfanos, D. (2015). Early cannabis use, polygenic risk score for schizophrenia and brain maturation in adolescence. JAMA Psychiatry, 72(10), 1002–1011. https://doi.org/10.1001/jamapsychiatry.2015.1131