| Zugriffsnummer | 37601 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex |
| Autor(in); Institution |
Guadalupe, T.; Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, THE NETHERLANDS
Mathias, S.R.; Department of Psychiatry, Yale School of Medicine, New Haven, USA
vanErp, T.; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
Whelan, C.; Imaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA
Zwiers, M.; Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, THE NETHERLANDS
Abe, Y.; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JAPAN
Abramovic, L.; Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, THE NETHERLANDS
Agartz, I.; NORMENT- KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, NORWAY
Andreassen, O.; NORMENT- KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, NORWAY
Arias-Vásquez, A.; Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, THE NETHERLANDS
Aribisala, B.; Department of Computer Science, Lagos State University, Lagos, NIGERIA
Francks, C.; Donders Institute for Brain, Cognition and Behaviour Raboud University Nijmegen, THE NETHERLANDS
Armstrong, N.; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, AUSTRALIA
Ittermann, Bernd; 8.1, Biomedizinische Magnetresonanz, PTB-Berlin
et al.,
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| Quelle/Jahr | Brain Imaging and Behavior: 11 (2017), 5, 1497 - 1514 |
| ISSN | 1931-7557 (PRINT) ; 1931-7565 (ONLINE) |
| DOI | |
| Verlag | Berlin: Springer |
| Freie Schlagworte | Subcortical brain asymmetry ; Age ; Handedness ; Sex ; Enigma ; Heritability ; Meta-analysis |
| Zusammenfassung | The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
| Weitere Informationen | 161 Authors, not all individual authors are listed ; 140 Institutions, not all institutions are listed |
Zitierung
Guadalupe, T., Mathias, S., vanErp, T., Whelan, C., Zwiers, M., Abe, Y., Abramovic, L., Agartz, I., Andreassen, O., Arias-Vásquez, A., Aribisala, B., Francks, C., Armstrong, N., Ittermann, B., & et al. (2017). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior, 11(5), 1497–1514. https://doi.org/10.1007/s11682-016-9629-z