| Zugriffsnummer | 36770 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Polygenic risk of psychosis and ventral striatal activation during reward processing in healthy adolescents |
| Autor(in); Institution |
Lancaster, T.M.; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
Linden, D.E.; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
Tansey, K.E.; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, Al.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Cattrell, A.; MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College, London, UK
Conrod, PJ.; Department of Psychiatry, Universite de Montreal, CHU Ste Jutine Hospital, Montreal, Quebec, CANADA
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Frouin, V.; Neurospin, Commissariat à l'Energie Atomique, Paris, FRANCE
Gallinat, J.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, P.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Heinz, A.; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Martinot, JP.; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1000, Neuroimaging and Psychiatry Research Unit, University Paris-Sud, Orsay, FRANCE
Paillère Martinot, ML.; INSERM, UMR 1000, Research Unit Imaging and Psychiatry, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay, FRANCE
Artiges, E.; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1000, Neuroimaging and Psychiatry Research Unit, University Paris-Sud, Orsay, Orsay Hospital, Orsay, FRANCE
Lemaitre, H.; Rotman Research Institute, Baycrest Health Sciences, and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Nees, F.; Rotman Research Institute, Baycrest Health Sciences, and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, CANADA
Orfanos, D.P.; Department of Child and Adolescent Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, AUSTRIA
Paus, T.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Poustka, L.; Department of Psychology, University College Dublin, Dublin, IRELAND
Smolka, MN.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Vetter, NC.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Jurk, S.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Mennigen, E.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Whelan, R.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Institute of Psychiatry, King's College London, London, UK
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| Quelle/Jahr | JAMA Psychiatry: 73 (2016), 8, 852 - 861 |
| ISSN | 2168-622X (PRINT) ; 2168-6238 (ONLINE) |
| DOI | |
| Verlag | Chicago, Ill.: American Medical Association (AMA) |
| Zusammenfassung | Importance Psychotic disorders are characterized by attenuated activity in the brain’s valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging. Objective To examine whether common risk variants for psychosis are associated with individual variation in the VS. Design, Setting, and Participants A cross-sectional study of a large cohort of adolescents from the IMAGEN study (a European multicenter study of reinforcement sensitivity in adolescents) was performed from March 1, 2008, through December 31, 2011. Data analysis was conducted from October 1, 2015, to January 9, 2016. Polygenic risk profile scores (RPSs) for psychosis were generated for 1841 healthy adolescents. Sample size and characteristics varied across regression analyses, depending on mutual information available (N = 1524-1836). Main Outcomes and Measures Reward-related brain function was assessed with blood oxygen level dependency (BOLD) in the VS using the monetary incentive delay (MID) task, distinguishing reward anticipation and receipt. Behavioral impulsivity, IQ, MID task performance, and VS BOLD were regressed against psychosis RPS at 4 progressive P thresholds (P ( .01, P ( .05, P ( .10, and P ( .50 for RPS models 1-4, respectively). Results In a sample of 1841 healthy adolescents (mean age, 14.5 years; 906 boys and 935 girls), we replicated an association between increasing psychosis RPS and reduced IQ (matrix reasoning: corrected P = .003 for RPS model 2, 0.4% variance explained), supporting the validity of the psychosis RPS models. We also found a nominally significant association between increased psychosis RPS and reduced MID task performance (uncorrected P = .03 for RPS model 4, 0.2% variance explained). Our main finding was a positive association between psychosis RPS and VS BOLD during reward anticipation at all 4 psychosis RPS models and for 2 P thresholds for reward receipt (RPS models 1 and 3), correcting for the familywise error rate (0.8%-1.9% variance explained). Conclusions and Relevance These findings support an association between psychosis RPS and VS BOLD in adolescents. Genetic risk for psychosis may shape an individual’s response to rewarding stimuli. |
Zitierung
Lancaster, T., Linden, D., Tansey, K., Banaschewski, T., Bokde, A., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J., Paillère Martinot, M., Artiges, E., Lemaitre, H., Nees, F., Orfanos, D., Paus, T., Poustka, L., Smolka, M., Vetter, N., Jurk, S., Mennigen, E., Walter, H., Whelan, R., & Schumann, G. (2016). Polygenic risk of psychosis and ventral striatal activation during reward processing in healthy adolescents. JAMA Psychiatry, 73(8), 852–861. https://doi.org/10.1001/jamapsychiatry.2016.1135