| Zugriffsnummer | 36095 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Using proton MR spectroscopy and quantitative susceptibility mapping (QSM) at 7 Tesla to decipher mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) |
| Autor(in); Institution |
Mekle, Ralf; 8.1, Medizinische Messtechnik, PTB-Berlin
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Niendorf, Th.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY
Huelnhagen, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY
Else, A.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GERMANY
Robinson, S.D.; High Field MR Centre, Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, Vienna, AUSTRIA
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Madai, V.; Department of Neurology and Center for Stroke Research Berlin, Charité-Universitätsmedizin, Berlin, GERMANY
Skowrońska, M.; 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, POLAND
Dušek, P.; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital in Prague, CZECH REPUBLIC
Wuerfel, J.; Medical Image Analysis Center, Basel, SWITZERLAND
Schneider, S.; Neurology Department, University of Kiel, Kiel, GERMANY
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| Quelle/Jahr | ISMRM 24th annual meeting & exhibition: 07 - 13 May 2016, Singapore:(2016), 3 S. |
| Availability | [USB-Stick] |
| Verlag | Berkeley, Calif.: ISMRM |
| Konferenzangaben | 24th ISMRM Annual Meeting & Exhibition, Singapore, 07 May – 13 May , 2016, Singapore |
| Zusammenfassung | Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a recently identified rare disorder from the neurodegeneration with brain iron accumulation (NBIA) group. The aim of this study was to apply 1H MR spectroscopy (MRS) in the white matter (WM) of the precentral region and quantitative susceptibility mapping (QSM) of basal ganglia at ultra-high (7 T) field in patients (homozygotes) and non-manifesting heterozygotes to elucidate underlying metabolic and structural changes of MPAN. Three patients, 9 heterozygotes, and 9 matched control subjects were scanned. Comparing patients versus controls resulted in significant increases for glutamate and taurine, of all 13 metabolites quantified. No significant differences between metabolite concentrations for heterozygotes and controls were detected, Results from QSM showed that susceptibility was significantly higher in globus pallidus and substantia nigra of patients compared to controls and heterozygotes. No difference in susceptibility was observed between heterozygotes and controls. Enhanced glutamate indicates a dysfunctional regulation of excitatory neurotransmission in patients. |
Zitierung
Mekle, R., Schubert, F., Niendorf, T., Huelnhagen, T., Else, A., Robinson, S., Ittermann, B., Madai, V., Skowrońska, M., Dušek, P., Wuerfel, J., & Schneider, S. (2016). Using proton MR spectroscopy and quantitative susceptibility mapping (QSM) at 7 Tesla to decipher mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN). 24th ISMRM Annual Meeting & Exhibition, Singapore, 07 May – 13 May , 2016, Singapore.