| Zugriffsnummer | 36020 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Neural basis of reward anticipation and its genetic determinants |
| Autor(in); Institution |
Jia, T.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London, UK
Macare, C.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London, UK
Desrivieres, S.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London, UK
Gonzalez, D. A.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Tao, C.; Center for Computational Systems Biology, Fudan University, Shanghai, CHINA
Ji, X.; Center for Computational Systems Biology, Fudan University, Shanghai, CHINA
Ruggeri, B.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London, UK
Nees, F.; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, GERMANY
Barker, G.J.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Bokde, A.L.; Trinity College Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; Department of System Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Büchel, C.; Department of System Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Conrod, P.J.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; Department of Psychiatry, Université de Montréal, Centre Hospitalier Universitaire Ste Justine Hospital, Montréal, QC, CANADA
Dove, R.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Frouin, V.; Neurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, FRANCE
Gallinat, J.; Department of Psychiatry and Psychology, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, GERMANY
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Gowland, P.; School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Heinz, A.; Clinic for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Lathrop, M.; McGill University and Genome Quebec Innovation Centre, Montréal, QC, CANADA
Lemaitre, H.; INSERM Commissariat à l'énergie atomique et aux énergies alternatives Unit 1000 “Imaging & Psychiatry,” University Paris Sud, Orsay, FRANCE
Martinot, J.-L.; INSERM Commissariat à l'énergie atomique et aux énergies alternatives Unit 1000 “Imaging & Psychiatry,” University Paris Sud, Orsay, FRANCE
Paus, T.; Rotman Research Institute, University of Toronto, Toronto, ON, CANADA; School of Psychology, University of Nottingham, Nottingham, UK
Pausova, Z.; The Hospital for Sick Children, University of Toronto, Toronto, ON, CANADA
Poline, J.-B.; Neurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, FRANCE; Henry H. Wheeler, Jr. Brain Imaging Center, University of California, Berkeley, CA, USA
Rietschel, M.; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, GERMANY
Robbins, T.; Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Smolka, M.N.; Department of Psychiatry and Psychotherapy, and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Müller, C.P.; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, GERMANY
Feng, J.; Center for Computational Systems Biology, Fudan University, Shanghai, CHINA
Rothenfluh, A.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Flor, H.; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, GERMANY
Schumann, G.; Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, London, UK
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| Quelle/Jahr | Proceedings of the National Academy of Sciences of the United States of America: 113 (2016), 14, 3879 - 3884 |
| ISSN | 0027-8424 (PRINT) ; 1091-6490 (ONLINE) |
| DOI | |
| Verlag | Washington, DC: NAS |
| Freie Schlagworte | GWAS ; VPS4A ; dopamine receptor ; fMRI ; neural network |
| Zusammenfassung | Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila. Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature. |
Zitierung
Jia, T., Macare, C., Desrivieres, S., Gonzalez, D. A., Tao, C., Ji, X., Ruggeri, B., Nees, F., Banaschewski, T., Barker, G., Bokde, A., Bromberg, U., Büchel, C., Conrod, P., Dove, R., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lathrop, M., Lemaitre, H., Martinot, J.-L., Paus, T., Pausova, Z., Poline, J.-B., Rietschel, M., Robbins, T., Smolka, M., Müller, C., Feng, J., Rothenfluh, A., Flor, H., & Schumann, G. (2016). Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences of the United States of America, 113(14), 3879–3884. https://doi.org/10.1073/pnas.1503252113