| Zugriffsnummer | 35701 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Energy dependent track structure parametrisations for protons and carbon ions based on nanometric simulations |
| Autor(in); Institution |
Alexander, Frauke; Technische Universität München, Klinikum rechts der Isar, Department of Radiation Oncology, München, GERMANY
Villagrasa, Carmen; Institut de Radioprotection et Sûreté nucléaire, Fontenay aux Roses, FRANCE
Rabus, Hans; 6.6, Strahlenwirkung, PTB-Braunschweig
Wilkens, Jan; Technische Universität München, Klinikum rechts der Isar, Department of Radiation Oncology, München, GERMANY
|
| Quelle/Jahr | The European Physical Journal D: 69 (2015), 216, 1 - 7 |
| ISSN | 1434-6060 (PRINT) ; 1434-6079 (ONLINE) |
| DOI | |
| Verlag | Orsay: EDP Sciences |
| Freie Schlagworte | Track structure ; BioQuaRT ; nanodosimetry ; treatment planning ; Geant4-DNA |
| Zusammenfassung | The BioQuaRT project within the European Metrology Research Programme aims at correlating ion track structure characteristics with the biological effects of radiation and develops measurement and simulation techniques for determining ion track structure on different length scales from about 2 nm to about 10 µm. Within this framework, we investigate methods to translate track-structure quantities derived on a nanometre scale to macroscopic dimensions. Input data sets were generated by simulations of ion tracks of protons and carbon ions in liquid water using the Geant4 Monte Carlo toolkit with the Geant4-DNA processes. Based on the energy transfer points - recorded with nanometre resolution – we investigated parametrisations of overall properties of ion track structure. Three different track structure parametrisations have been developed using the distances to the 10 next neighbouring ionisations, the radial energy distribution and ionisation cluster size distributions. These parametrisations of nanometric track structure build a basis for deriving biologically relevant mean values which are essential in the clinical situation where each voxel is exposed to a mixed radiation field. |
| Kostenfreier Zugang | Open Access Hybrid |