| Zugriffsnummer | 35591 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Incomplete hippocampal inversion: a comprehensive MRI study of over 2000 subjects |
| Autor(in); Institution |
Cury, C.; Institut national de la santé et de la recherche médicale, Paris, FRANCE
Toro, R.; Centre National de la Recherche Scientifique, Genes, Synapses and Cognition, Institut Pasteur, Paris, FRANCE
Cohen, F.; Institut national de la santé et de la recherche médicale, Paris, FRANCE
Fischer, C.; Centre d'Acquisition et de Traitement des Images, Paris, FRANCE
Mhaya, A.; Institut national de la santé et de la recherche médicale, Paris, FRANCE
Samper-Gonzalez, J.; Institut national de la santé et de la recherche médicale, Paris, FRANCE
Hasboun, D.; Institut national de la santé et de la recherche médicale, Paris, FRANCE
Mangin, J.; Centre d'Acquisition et de Traitement des Images, Paris, FRANCE
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND
Bromberg, U.; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Buechel, C.; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Cattrell, A.; Department of Psychology, Stanford University, Stanford, CA, USA
Conrod, P.; Department of Psychology, Stanford University, Stanford, CA, USA
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Gallinat, J.; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Garavan, H.; Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND
Gowland, P.; School of Physics and Astronomy, University of Nottingham, Nottingham, UK
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité–Universitätsmedizin Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Lemaitre, H.; Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes, Paris, FRANCE
Martinot, J.; Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes, Paris, FRANCE
Nees, F.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Paillere, M.; Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes, Paris, FRANCE
Orfanos, D.; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant, Gif-Sur-Yvette, FRANCE
Paus, T.; Rotman Research Institute, Baycrest, Toronto, CANADA
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, GERMANY
Smolka, M.; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité–Universitätsmedizin Berlin, GERMANY
Whelan, R.; Department of Psychology, University College Dublin, Dublin, IRELAND
Frouin, V.; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant, Gif-Sur-Yvette, FRANCE
Schumann, G.; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Glaunes, J.; MAP5, Université Paris Descartes, Sorbonne Paris Cité, Paris, FRANCE
Colliot, O.; Institut national de la santé et de la recherche médicale, Paris, FRANCE
IMAGEN concortium,
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| Quelle/Jahr | Frontiers in Neuroanatomy: 9 (2015), 12 S. |
| Availability | [online only] |
| ISSN | 1662-5129 |
| DOI | |
| Verlag | Lausanne: Frontiers Research Foundation |
| Zusammenfassung | The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, x2-test, p < 10-28). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Cury, C., Toro, R., Cohen, F., Fischer, C., Mhaya, A., Samper-Gonzalez, J., Hasboun, D., Mangin, J., Banaschewski, T., Bokde, A., Bromberg, U., Buechel, C., Cattrell, A., Conrod, P., Flor, H., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaitre, H., Martinot, J., Nees, F., Paillere, M., Orfanos, D., Paus, T., Poustka, L., Smolka, M., Walter, H., Whelan, R., Frouin, V., Schumann, G., Glaunes, J., Colliot, O., & IMAGEN concortium. (2015). Incomplete hippocampal inversion: a comprehensive MRI study of over 2000 subjects. Frontiers in Neuroanatomy, 9, 12 S. https://doi.org/10.3389/fnana.2015.00160