| Zugriffsnummer | 35552 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | The role of the cannabinoid receptor in adolescents' processing of facial expressions |
| Autor(in); Institution |
Ewald, A.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Becker, S.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Heinrich, A.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Bokde, A.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin, IRELAND
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Bromberg, U.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Cattrell, A.; Institute of Psychiatry, King's College London, London, UK
Conrod, P.; Institute of Psychiatry, King's College London, London, UK
Desrivières, S.; Institute of Psychiatry, King's College London, London, UK
Frouin, V.; Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, FRANCE
Papadopoulos-Orfanos, D.; Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, FRANCE
Gallinat, J.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Heinz, A.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Walter, H.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Gowland, P.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Paus, T.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, GERMANY
Martinot, J.; INSERM, UMR 1000, Research Unit Imaging and Psychiatry, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay, FRANCE
Paillère Martinot, M.; INSERM, UMR 1000, Research Unit Imaging and Psychiatry, CEA, DSV, I2BM-Service Hospitalier Frédéric Joliot, Orsay, FRANCE
Smolka, M.; Department of Psychiatry and Psychotherapy, Faculty of Medicine Carl Gustav Carus, Section of Systems Neuroscience, Technische Universität Dresden, Dresden, GERMANY
Vetter, N.; Department of Psychiatry and Psychotherapy, Faculty of Medicine Carl Gustav Carus, Section of Systems Neuroscience, Technische Universität Dresden, Dresden, GERMANY
Whelan, R.; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin, IRELAND
Schumann, G.; Institute of Psychiatry, King's College London, London, UK
Flor, H.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Nees, F.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
IMAGEN concortium,
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| Quelle/Jahr | European Journal of Neuroscience: 43 (2016), 1, 98 - 105 |
| ISSN | 0953-816X (PRINT) ; 1460-9568 (ONLINE) |
| DOI | |
| Verlag | Oxford: Blackwell Science |
| Zusammenfassung | The processing of emotional faces is an important prerequisite for adequate social interactions in daily life, and might thus specifically be altered in adolescence, a period marked by significant changes in social emotional processing. Previous research has shown that the cannabinoid receptor CB1R is associated with longer gaze duration and increased brain responses in the striatum to happy faces in adults, yet, for adolescents, it is not clear whether an association between CBR1 and face processing exists. In the present study we investigated genetic effects of the two CB1R polymorphisms, rs1049353 and rs806377, on the processing of emotional faces in healthy adolescents. They participated in functional magnetic resonance imaging during a Faces Task, watching blocks of video clips with angry and neutral facial expressions, and completed a Morphed Faces Task in the laboratory where they looked at different facial expressions that switched from anger to fear or sadness or from happiness to fear or sadness, and labelled them according to these four emotional expressions. A-allele versus GG-carriers in rs1049353 displayed earlier recognition of facial expressions changing from anger to sadness or fear, but not for expressions changing from happiness to sadness or fear, and higher brain responses to angry, but not neutral, faces in the amygdala and insula. For rs806377 no significant effects emerged. This suggests that rs1049353 is involved in the processing of negative facial expressions with relation to anger in adolescence. These findings add to our understanding of social emotion-related mechanisms in this life period. |
Zitierung
Ewald, A., Becker, S., Heinrich, A., Banaschewski, T., Poustka, L., Bokde, A., Büchel, C., Bromberg, U., Cattrell, A., Conrod, P., Desrivières, S., Frouin, V., Papadopoulos-Orfanos, D., Gallinat, J., Garavan, H., Heinz, A., Walter, H., Ittermann, B., Gowland, P., Paus, T., Martinot, J., Paillère Martinot, M., Smolka, M., Vetter, N., Whelan, R., Schumann, G., Flor, H., Nees, F., & IMAGEN concortium. (2016). The role of the cannabinoid receptor in adolescents' processing of facial expressions. European Journal of Neuroscience, 43(1), 98–105. https://doi.org/10.1111/ejn.13118